Cat. No. 3831
Chemical Name: (2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetr
Biological ActivityNovel RXR:PPARγ agonist; sensitizes PPARγ by enhancing its ligand binding activity. Also activates RXR:RAR and RXR:PPARα heterodimers in cotransfection assays. Displays selectivity over other permissive heterodimers such as RXR:LXRα and RXR:BAR/FXR. Exhibits antidiabetic properties in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Cesario et al (2001) The retinoid LG100754 is a novel RXR:PPARγ agonist and decreases glucose levels in vivo. Mol.Endocrinol. 15 1360. PMID: 11463859.
Forman (2002) The antidiabetic agent LG100754 sensitizes cells to low concentrations of peroxisome proliferator-activated receptor γ ligands. J.Biol.Chem. 277 12503. PMID: 11877384.
Germain et al (2006) International union of pharmacology LXIII. Retinoid X receptors. Pharmacol.Rev. 58 760. PMID: 17132853.
Sato et al (2010) The "Phantom Effect" of the rexinoid LG100754: structural and functional insights. PLoS One 5 e15119. PMID: 21152046.
If you know of a relevant citation for this product please let us know.
Keywords: LG 100754, supplier, LG100754, selective, retinoid, x, receptors, RXR, nuclear, receptors, ppar, peroxisome, proliferator, activated, receptors, PPARgamma, PPARg, PPARγ, agonists, sensitizers
Find multiple products by catalog number
New Products in this Area
Thyroid hormone (T3) analog; also promotes adipogenic differentiation of MSCsCINPA 1
Potent CAR antagonist
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.