Cat. No. 3831
Chemical Name: (2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoic acid
Biological ActivityNovel RXR:PPARγ agonist; sensitizes PPARγ by enhancing its ligand binding activity. Also activates RXR:RAR and RXR:PPARα heterodimers in cotransfection assays. Displays selectivity over other permissive heterodimers such as RXR:LXRα and RXR:BAR/FXR. Exhibits antidiabetic properties in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Cesario et al (2001) The retinoid LG100754 is a novel RXR:PPARγ agonist and decreases glucose levels in vivo. Mol.Endocrinol. 15 1360. PMID: 11463859.
Forman (2002) The antidiabetic agent LG100754 sensitizes cells to low concentrations of peroxisome proliferator-activated receptor γ ligands. J.Biol.Chem. 277 12503. PMID: 11877384.
Germain et al (2006) International union of pharmacology LXIII. Retinoid X receptors. Pharmacol.Rev. 58 760. PMID: 17132853.
Sato et al (2010) The "Phantom Effect" of the rexinoid LG100754: structural and functional insights. PLoS One 5 e15119. PMID: 21152046.
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Keywords: LG 100754, supplier, LG100754, selective, retinoid, x, receptors, RXR, nuclear, receptors, ppar, peroxisome, proliferator, activated, receptors, PPARgamma, PPARg, PPARγ, agonists, sensitizers
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