R&D Systems Inc. Tocris Bioscience Boston Biochem

LG 100754

Cat. No. 3831

LG 100754 C26H36O3 [180713-37-5]

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Chemical Name: (2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoic acid

Biological Activity

Novel RXR:PPARγ agonist; sensitizes PPARγ by enhancing its ligand binding activity. Also activates RXR:RAR and RXR:PPARα heterodimers in cotransfection assays. Displays selectivity over other permissive heterodimers such as RXR:LXRα and RXR:BAR/FXR. Exhibits antidiabetic properties in vivo.

Technical Data

M.Wt:
396.56
Formula:
C26H36O3
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
180713-37-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Cesario et al (2001) The retinoid LG100754 is a novel RXR:PPARγ agonist and decreases glucose levels in vivo. Mol.Endocrinol. 15 1360. PMID: 11463859.

Forman (2002) The antidiabetic agent LG100754 sensitizes cells to low concentrations of peroxisome proliferator-activated receptor γ ligands. J.Biol.Chem. 277 12503. PMID: 11877384.

Germain et al (2006) International union of pharmacology LXIII. Retinoid X receptors. Pharmacol.Rev. 58 760. PMID: 17132853.

Sato et al (2010) The "Phantom Effect" of the rexinoid LG100754: structural and functional insights. PLoS One 5 e15119. PMID: 21152046.

If you know of a relevant citation for this product please let us know.

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Keywords: LG 100754, supplier, LG100754, selective, retinoid, x, receptors, RXR, nuclear, receptors, ppar, peroxisome, proliferator, activated, receptors, PPARgamma, PPARg, PPARγ, agonists, sensitizers

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