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NF 340

Cat No. 3830

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Chemical Name: 4,4'-(Carbonylbis(imino-3,1-(4-methyl-phenylene)carbony limino))bis(naphthalene-2,6-disulfonic acid) tetrasodium salt

Biological Activity

P2Y₁₁ antagonist; exhibits 520-fold selectivity for P2Y₁₁ over P2Y₁, P2Y₂, P2Y₄, P2Y₆ and P2Y₁₂ receptors. Displays competitive antagonism against ATPγS (pIC₅₀ values are 6.43 and 7.14 in Ca²⁺ and cAMP assays respectively).

Technical Data

M.Wt:

986.84

Formula:

C₃₇H₂₆N₄Na₄O₁₅S₄

Solubility:

Soluble to 40 mM in water and to 20 mM in DMSO

Purity:

>95 %

Storage:

Store at -20°C

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Meis et al (2010) NF546 [4,4'-(carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-alpha,alpha'-diphosphonic acid) tetrasodium salt] is a non-nucleotide P2Y11 agonist and stimulates release of interleukin-8 from human monocyte-derived dendritic cells. J.Pharmacol.Exp.Ther. 332 238.

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Purinergic (P2Y) Receptors

Keywords: NF 340, P2Y11, purinoceptors, purines, receptors, antagonists, NF340

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