7,8-Dihydroxyflavone

Cat. No. 3826

7,8-Dihydroxyflavone C15H10O4 [38183-03-8]

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Alternative Name: 7,8-DHF

Chemical Name: 7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one

Biological Activity

Tyrosine kinase receptor B (TrkB) agonist that binds to the extracellular domain of the receptor (Kd = 320 nM). Inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro and in vivo. Exhibits neuroprotective effects in an HD mouse model.

Technical Data

M.Wt:
254.24
Formula:
C15H10O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in 2eq. NaOH
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
38183-03-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Jang et al (2010) A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc.Natl.Acad.Sci.USA 107 268.

Andero et al (2012) 7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilzation stress in rats. Hippocampus 22 399. PMID: 21136519.

Jiang et al (2013) Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease. Hum.Mol.Genet. 22 2462. PMID: 23446639.

If you know of a relevant citation for this product please let us know.

Keywords: 7,8-Dihydroxyflavone, supplier, agonists, TrkB, Neurotrophin, Receptors, Tyrosine, Kinases, RTKs, 7,8-DHF

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