R&D Systems Inc. Tocris Bioscience Boston Biochem

7,8-Dihydroxyflavone

Cat. No. 3826

7,8-Dihydroxyflavone C15H10O4 [38183-03-8]

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Alternative Name: 7,8-DHF

Chemical Name: 7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one

Biological Activity

Tyrosine kinase receptor B (TrkB) agonist that binds to the extracellular domain of the receptor (Kd = 320 nM). Inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro and in vivo. Exhibits neuroprotective effects in an HD mouse model.

Technical Data

M.Wt:
254.24
Formula:
C15H10O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in 2eq. NaOH
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
38183-03-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Jang et al (2010) A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc.Natl.Acad.Sci.USA 107 268.

Andero et al (2012) 7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilzation stress in rats. Hippocampus 22 399. PMID: 21136519.

Jiang et al (2013) Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease. Hum.Mol.Genet. 22 2462. PMID: 23446639.

If you know of a relevant citation for this product please let us know.

Keywords: 7,8-Dihydroxyflavone, supplier, agonists, TrkB, Neurotrophin, Receptors, Tyrosine, Kinases, RTKs, 7,8-DHF

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