Cat. No. 3826
Alternative Name: 7,8-DHF
Chemical Name: 7,8-Dihydroxy-2-phenyl-4H-1-benzopy
Biological ActivityTyrosine kinase receptor B (TrkB) agonist that binds to the extracellular domain of the receptor (Kd = 320 nM). Inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro and in vivo. Exhibits neuroprotective effects in an HD mouse model.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Jang et al (2010) A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc.Natl.Acad.Sci.USA 107 268.
Andero et al (2012) 7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilzation stress in rats. Hippocampus 22 399. PMID: 21136519.
Jiang et al (2013) Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease. Hum.Mol.Genet. 22 2462. PMID: 23446639.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: 7,8-Dihydroxyflavone, supplier, agonists, TrkB, Neurotrophin, Receptors, Tyrosine, Kinases, RTKs, 7,8-DHF, Trk Receptor Agonists
Find multiple products by catalog number
New Products in this Area
Potent VEGFR inhibitor; also aromatase inhibitorPF 06463922
High affinity and selective ALK and ROS1 inhibitor6bK
Insulin degrading enzyme (IDE) inhibitorCrizotinib
Potent c-MET/ALK inhibitor
January 12, 2016