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Liquiritigenin

Cat. No. 3819

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Chemical Name: (S)-2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Biological Activity

Potent ERβ agonist isolated from licorice root (EC₅₀ = 36.5 nM for activation of the ERE tk-Luc reporter by ERβ in transfected U2OS cells). Displays 20-fold selectivity for ERβ; does not activate other nuclear receptors, including the androgen and glucocorticoid receptors. Displays anti-inflammatory effects.

Technical Data

M.Wt:

256.25

Formula:

C₁₅H₁₂O₄

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

>98 %

Storage:

Store at +4°C

CAS No:

578-86-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

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Safety Data Sheet: View Safety Data Sheet

References

Yahara (1984) Flavonoid glucosides from licorice. Phytochemistry 23 2108.

Kim et al (2008) Anti-inflammatory effects of liquiritigenin as a consequence of the inhibition of NK-kappaB-dependent iNOS and proinflammatory cytokines production. Br.J.Pharmacol. 154 165. PMID: 18332856.

Mersereau et al (2008) Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist. Mol.Cell.Endocrinol. 283 49. PMID: 18177995.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Estrogen Receptors

Keywords: Liquiritigenin, supplier, ERβ, ERb, ERbeta, selective, agonists, ERR, estrogen, receptors, anti-inflammatories, antiinflammatory

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