R&D Systems Inc. Tocris Bioscience Boston Biochem

R 568 hydrochloride

Cat. No. 3815

R 568 hydrochloride C18H22ClNO.HCl [177172-49-5]

Price and Availability

For R 568 hydrochloride pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanamine hydrochloride

Biological Activity

Positive allosteric modulator and allosteric agonist of the human calcium-sensing receptor (hCaSR). Exhibits calcimimetic activity. Has the ability to restore function to hCaSR mutants that cause familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT). Exerts a suppressive effect on parathyroid (PT) hormone secretion; inhibits PT cell proliferation in rats with renal insufficiency.

Technical Data

M.Wt:
340.29
Formula:
C18H22ClNO.HCl
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
177172-49-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Wada et al (1997) The calcimimetic compound NPS R-568 suppresses parathyroid cell proliferation in rats with renal insufficiency. J.Clin.Invest. 100 2977. PMID: 9399943.

Fox et al (1999) NPS R-568: a type II calcimimetic compound that acts on parathyroid cell calcium receptor of rats to reduce plasma levels of parathyroid hormone and calcium. J.Pharmacol.Exp.Ther. 290 473. PMID: 10411552.

Ying Lin Lu et al (2009) Effect of the calcimimetic R-568 [3-(2-chlorophenyl)-N-((1R)-1-(3-methoxyphenyl)ethyl)-1-propanamine] on correcting inactivating mutations in the human calcium-sensing receptor. J.Pharmacol.Exp.Ther. 331 775. PMID: 19759318.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: R 568 hydrochloride, supplier, R568, hydrochloride, HCl, allosteric, modulators, and, allosteric, agonists, calcium-sensing, recptor, hCaSR

Quick Order

Find multiple products by catalog number

divider line

New Product E-alerts

Sign up for email updates from Tocris

e-alerts

Enter your email address below to sign up to receive our email updates:

divider line

New Products in this Area

NIBR 189

Potent and selective EBI2 (GPR183) receptor antagonist

ONO AE3 208

High affinity and selective EP4 antagonist

TCS 3035

GPR35 agonist

PF 5274857 hydrochloride

Potent and selective Smoothened (Smo) receptor antagonist

GSK 137647

Potent and selective FFA4 (GPR120) agonist

AH 7614

Selective FFA4 (GPR120) antagonist

Sign-up for new product e-alerts
divider line

Bio-Techne Events

2014 ASCB/IFCB meeting

ASCB/IFCB 2014

December 6 - 10, 2014

Philadelphia, USA

Booth Number: 515