Repaglinide

Cat. No. 3805

Repaglinide C27H36N2O4 [135062-02-1]

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Alternative Name: AG-EE 623ZW

Chemical Name: 2-Ethoxy-4-[2-[[(1S)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]benzoic acid

Biological Activity

Kir6 (KATP) channel blocker that binds with high affinity for SUR1 when co-expressed with Kir6.2 (Kd = 0.42 nM). Antidiabetic glucose regulator with hypoglycaemic effect in vivo.

Technical Data

M.Wt:
452.59
Formula:
C27H36N2O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
135062-02-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Mark and Grell (1997) Hypoglycaemic effects of the novel antidiabetic agent repaglinide in rats and dogs. Br.J.Pharmacol. 121 1597. PMID: 9283692.

Hansen et al (2005) Kir6.2-dependent high-affinity repaglinide binding to β-cell KATP channels. Br.J.Pharmacol. 144 551. PMID: 15678092.

If you know of a relevant citation for this product please let us know.

View Related Products by Product Action

Keywords: Repaglinide, supplier, K+, channel, pore, blockers, KATP, Blocks, SUR1, KIR6, Kir6.2, sulphonylurea, receptor, inward, rectifier, Tocris Bioscience, Inward Rectifier Potassium (Kir) Channel Blockers

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