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Repaglinide

Cat. No. 3805

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Alternative Name: AG-EE 623ZW

Chemical Name: 2-Ethoxy-4-[2-[[(1S)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]benzoic acid

Biological Activity

K_ir6 (K_ATP) channel blocker that binds with high affinity for SUR1 when co-expressed with K_ir6.2 (K_d = 0.42 nM). Antidiabetic glucose regulator with hypoglycaemic effect in vivo.

Technical Data

M.Wt:

452.59

Formula:

C₂₇H₃₆N₂O₄

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

>99 %

Storage:

Store at +4°C

CAS No:

135062-02-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Mark and Grell (1997) Hypoglycaemic effects of the novel antidiabetic agent repaglinide in rats and dogs. Br.J.Pharmacol. 121 1597. PMID: 9283692.

Hansen et al (2005) Kir6.2-dependent high-affinity repaglinide binding to β-cell K_ATP channels. Br.J.Pharmacol. 144 551. PMID: 15678092.

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