Cat. No. 3805
Alternative Name: AG-EE 623ZW
Chemical Name: 2-Ethoxy-4-[2-[[(1S)-3-methyl-1-[2-
Biological ActivityKir6 (KATP) channel blocker that binds with high affinity for SUR1 when co-expressed with Kir6.2 (Kd = 0.42 nM). Antidiabetic glucose regulator with hypoglycaemic effect in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Mark and Grell (1997) Hypoglycaemic effects of the novel antidiabetic agent repaglinide in rats and dogs. Br.J.Pharmacol. 121 1597. PMID: 9283692.
Hansen et al (2005) Kir6.2-dependent high-affinity repaglinide binding to β-cell KATP channels. Br.J.Pharmacol. 144 551. PMID: 15678092.
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Keywords: Repaglinide, supplier, K+, channel, pore, blockers, KATP, Blocks, SUR1, KIR6, Kir6.2, sulphonylurea, receptor, inward, rectifier
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