Home » Research Area » » Ion Channels » Potassium Channels » Calcium-Activated Potassium (K_Ca) Channels » NS 1619

NS 1619

Cat. No. 3804

Price and Availability

For NS 1619 pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one

Biological Activity

Large-conductance Ca²⁺-activated potassium (BK_Ca, K_Ca1.1) channel activator. Induces a concentration-dependent decrease in mitochondrial membrane potential (EC₅₀ = 3.6 μM).

Technical Data

M.Wt:

362.23

Formula:

C₁₅H₈F₆N₂O₂

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

>98 %

Storage:

Store at +4°C

CAS No:

153587-01-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Select another batch:

Safety Data Sheet: View Safety Data Sheet

References

Olesen et al (1994) Selective activation of Ca(2+)-dependent K⁺ channels by novel benzimidazolone. Eur.J.Pharmacol. 251 53. PMID: 8137869.

Debska et al (2003) Large-conductance K⁺ channel openers NS1619 and NS004 as inhibitors of mitochondrial function in glioma cells. Biochem.Pharmacol. 65 1827. PMID: 12781334.

Han et al (2008) The potassium ion channel opener NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells. Biochem.Biophys.Res.Comm. 375 205.

If you know of a relevant citation for this product please let us know.