R&D Systems Inc. Tocris Bioscience Boston Biochem

ITX 3

Cat. No. 3792

ITX 3 C22H17N3OS [347323-96-0]

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Chemical Name: (E)-2-[(2,5-Dimethyl-1-phenyl-1H-pyrrol-3-yl)methylene]thiazolo[3,2-a]benzimidazol-3(2H)-one

Biological Activity

Selective inhibitor of TrioN RhoGEF activity. Inhibits TrioN-mediated GTP exchange on RhoG and Rac1, formation of TrioN-induced cellular structures in REF52 fibroblasts and NGF-mediated neurite outgrowth in PC12 cells in vitro.

Technical Data

M.Wt:
371.45
Formula:
C22H17N3OS
Solubility:
Soluble to 5 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
347323-96-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Bouquier et al (2009) A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway. Chem.Biol. 16 657. PMID: 19549603.

If you know of a relevant citation for this product please let us know.

Keywords: ITX 3, supplier, ITX3, selective, TrioN, RhoGEFs, guanine, nucleotide, exchange, factors, inhibitors, RhoG, Rac1, GTPases, small, G, proteins

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