Cat. No. 3792
Chemical Name: (E)-2-[(2,5-Dimethyl-1-phenyl-1H-py
Biological ActivitySelective inhibitor of TrioN RhoGEF activity. Inhibits TrioN-mediated GTP exchange on RhoG and Rac1, formation of TrioN-induced cellular structures in REF52 fibroblasts and NGF-mediated neurite outgrowth in PC12 cells in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Bouquier et al (2009) A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway. Chem.Biol. 16 657. PMID: 19549603.
If you know of a relevant citation for this product please let us know.
Keywords: ITX 3, supplier, ITX3, selective, TrioN, RhoGEFs, guanine, nucleotide, exchange, factors, inhibitors, RhoG, Rac1, GTPases, small, G, proteins
Find multiple products by catalog number
New Products in this Area
High affinity PDEδ-KRAS interaction inhibitorESI 09
RalA and RalB GTPase inhibitorHydroxy Dynasore
Dynamin inhibitor; analog of dynasore (Cat. No. 2897)Rhosin hydrochloride
Rho GTPase inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.