Cat. No. 3792
Chemical Name: (E)-2-[(2,5-Dimethyl-1-phenyl-1H-py
Biological ActivitySelective inhibitor of TrioN RhoGEF activity. Inhibits TrioN-mediated GTP exchange on RhoG and Rac1, formation of TrioN-induced cellular structures in REF52 fibroblasts and NGF-mediated neurite outgrowth in PC12 cells in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
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Certificate of Analysis / Safety Data Sheet
Bouquier et al (2009) A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway. Chem.Biol. 16 657. PMID: 19549603.
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Keywords: ITX 3, supplier, ITX3, selective, TrioN, RhoGEFs, guanine, nucleotide, exchange, factors, inhibitors, RhoG, Rac1, GTPases, small, G, proteins