ViomycinCat No.
3787
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Price and Availability |
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Chemical Name: (S)-3,6-Diamino-N-((3S,9S,12S,15S,Z)3((2R,4S)-6-amino-4 -hydroxy-1,2,3,4-tetrahydropyridin-2-yl)-9,12-bis(hydro xymethyl)-2,5,8,11,14-pentaoxo-6-(ureidomethylene)-1,4, 7,10,13-pentaazacyclohexadecan-15-yl)hexanamide disulfate |
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Biological Activity
Member of the tuberactinomycin family of antibiotics. Inhibits group I intron splicing and prokaryotic protein synthesis. Freezes bacterial ribosomes in either the pre- or post-translational state. Facilitates trans-cleavage of the Neurospora VS ribozyme.Licensing Information
Sold for research purposes under agreement from Pfizer IncTechnical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Ermolenko et al (2007) The antibiotic viomycin traps the ribosome in an intermediate state of translocation. 14 493. Hausner et al (1988) The allosteric three-site model for the ribosomal elongation cycle. J.Biol.Chem. 263 13103. Schroeder et al (2000) Modulation of RNA function by aminoglycoside antibiotics. EMBO J. 19 1.If you know of a useful citation for this product please let us know.
Keywords: Viomycin, Pfizer, antibiotic, inhibits, inhibitors, bacterial, DNA, synthesis
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