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CelecoxibCat. No. 3786 |
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Alternative Names: SC 58635, Celebrex Chemical Name: 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide |
Biological Activity
Selective cyclooxygenase-2 (COX-2) inhibitor (IC50 values are 15 and 0.04 μM for COX-1 and COX-2 respectively). Anti-inflammatory with shorter plasma half-life in vivo than SC 58121 (Cat. No. 2895). Displays chemopreventive activity in in vivo tumor models.Licensing Information
Sold for research purposes under agreement from Pfizer Inc.Certificate of Analysis / Safety Data Sheet
References
Penning et al (1997) Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib). J.Med.Chem. 40 1347. PMID: 9135032.
DeWitt (1999) Cox-2-selective Inhibitors: the new super aspirins. Mol.Pharmacol. 55 625. PMID: 10101019.
Harris et al (2000) Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor. Cancer Res. 60 2101. PMID: 10786667.
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Keywords: Celecoxib, supplier, Selective, cyclooxygenase-2, COX-2, inhibitors, Oxygenases, Oxidases, SC58635, Pfizer
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