R&D Systems Inc. Tocris Bioscience Boston Biochem

CP 135807

Cat. No. 3783

CP 135807 C19H21N5O2 [151272-90-1]

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Chemical Name: 3-[[(2R)-1-Methyl-2-pyrrolidinyl]me­thyl]-N-(3-nitro-2-pyridinyl)-1H-indol-5-amine

Biological Activity

Selective 5-HT1D receptor agonist. Produces dose-dependent decreases in extracellular 5-HT concentration.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
351.4
Formula:
C19H21N5O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
151272-90-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Mansbach et al (1996) CP-135,807, a selective 5-HT1D agonist: effects in drug discrimination and punishment procedures in the pigeon. Psychopharmacology 128 313. PMID: 8972551.

Rollema et al (1996) Combined administration of a 5-hydroxytryptamine (5-HT)1D antagonist and a 5-HT reuptake inhibitor synergistically increases 5-HT release in guinea pig hypothalamus in vivo. J.Neurochem. 67 2204. PMID: 8863532.

Hertel et al (1999) The antipsychotic drug risperidone interacts with auto- and hetero-receptors regulating serotonin output in the rat frontal cortex. Neuropharmacology 38 1175. PMID: 10462130.

If you know of a relevant citation for this product please let us know.

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Keywords: CP 135807, supplier, selective, 5-HT, serotonin, 5-HT1D, receptors, agonists, Pfizer, CP135807

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