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SC 51089

Cat. No. 3758

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Chemical Name: 8-Chlorodibenz(Z)[b,f][1,4]oxazepine-10(11H)-carboxylic acid 2-[1-oxo-3-(4-pyridinyl)propyl]hydrazide hydrochloride

Biological Activity

Selective EP₁ prostanoid receptor antagonist (K_i values are 1.3, 11.2, 17.5, 61.1, > 100, > 100, > 100, >100 and > 100 μM for EP₁, TP, EP₃, EP₂, EP₄, FP and DP receptors respectively). Attenuates PGE₂-induced neuronal cell death in vitro and slows tumor growth in vivo.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:

459.33

Formula:

C₂₂H₁₉CIN₄O₃.HCl

Solubility:

Soluble to 100 mM in DMSO

Purity:

>99 %

Storage:

Store at -20°C

CAS No:

146033-02-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Abramovitz et al (2000) The utilization of recombinant prostanoid receptors determine the affinities and selectivities of prostaglandins and related analogs. Biochim.Biophys.Acta 1483 285. PMID: 10634944.

Matsuo et al (2004) Inhibition of human glioma cell growth by a PHS-2 inhibitor, NS398, and a prostaglandin E receptor subtype EP₁-selective antagonist. J.Neurochem. 66 285.

Saleem et al (2007) Effect of EP₁ receptor on cerebral blood flow in the middle cerebral artery occlusion model of stroke in mice. J.Neurosci.Res. 85 2433. PMID: 17600836.

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Keywords: SC 51089, supplier, SC51089, selective, EP1, receptors, antagonists, prostanoids, PGE2, prostaglandins, prostacyclins, eicosanoids, Pfizer

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