R&D Systems Inc. Tocris Bioscience Boston Biochem

Maraviroc

Cat. No. 3756

Maraviroc C29H41F2N5O [376348-65-1]

Price and Availability

For Maraviroc pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: UK-427857

Chemical Name: 4,4-Difluoro-N-{(1S)-3-[3-(3-isopropyl- 5-methyl-4H-1,2,4-triazol-4-yl)- 8-azabicyclo[3.2.1]oct-8-yl]-1- phenylpropyl}cyclohexanecarboxamide

Biological Activity

Selective CCR5 antagonist; displays potent anti-HIV-1 activity. Prevents the interaction of HIV-1 gp120 and CCR5 (IC50 = 6.4 nM), inhibiting HIV-1 entry. Also inhibits CCL3 (MIP-1α) binding to CCR5.

Licensing Information

Sold for research purposes under agreement from Viiv.

Technical Data

M.Wt:
513.67
Formula:
C29H41F2N5O
Solubility:
Soluble to 75 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
376348-65-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Dorr et al (2005) Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity. Antimicrob.Agents Chemother. 49 4721. PMID: 16251317.

Kuritzkes et al (2008) Fresh from the pipeline - maraviroc. Nat.Rev.Drug Discov. 7 15.

Garcia-Perez et al (2011) New insights into the mechanisms whereby low molecular weight CCR5 ligands inhibit HIV-1 infection. J.Biol.Chem. 286 4978. PMID: 21118814.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Maraviroc, supplier, UK-427857, HIV-1, gp120, CCR5, chemokine, receptors, ligands, selective, antagonists, HIV

Quick Order

Find multiple products by catalog number

divider line

Immunology Guide

Immunology Research Guide

Highlights over 150 products for immunology research. Request a copy or view PDF today.

divider line

New Therapies and Challenges in Asthma

Written by Peter J. Barnes

Asthma Poster

'New Therapies, Challenges, and Breakthroughs in Asthma' highlights key pathways and new therapies used to treat asthma, including those currently in clinical development.

divider line

7-TM Receptor Signaling

Written by T. Kenakin et al

7-TM Poster

'Seven Transmembrane Receptor Signaling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy

divider line

VEGF Pathway & Anti-Angiogenic Therapy

Written by N. Ferrara & Y. Crawford

Angiogenesis Poster

A summary of antiangiogenic therapies targeting the VEGF pathway and the mechanisms of therapy resistance.

divider line

New Product Guide

NPG

Highlights 140 new products added in the first half of 2014. Request a copy or view PDF today.

divider line

New Products in this Area

GSK 137647

Potent and selective FFA4 (GPR120) agonist

AH 7614

Selective FFA4 (GPR120) antagonist

Prosaptide TX14(A)

Potent GPR37 and GPR37L1 agonist

AS 2034178

Selective FFA1 (GPR40) agonist

(±)-NBI 74330

Potent and selective CXCR3 antagonist

Purmorphamine

Smo receptor agonist

CTCE 9908

CXCR4 antagonist; antitumor

VUF 11207 fumarate

Potent CXCR7 agonist

TC-G 1006

Potent and selective sphingosine-1-phosphate receptor 1 (S1P1) agonist

Sign-up for new product e-alerts
divider line

Bio-Techne Events

Annual Meeting of the Japan Neuroscience Society

Annual Meeting of the Japan Neuroscience Society

September 11 - 13, 2014

Yokohama, Japan