RN 1734

Cat. No. 3746

RN 1734 C14H22Cl2N2O2S [946387-07-1]

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Chemical Name: 2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide

Biological Activity

Selective TRPV4 antagonist (IC50 values are 2.3, 3.2 and 5.9 μM for hTRPV4, rTRPV4 and mTRPV4 receptors respectively). Displays selectivity for TRPV4 over other TRP channels (IC50 values are 2.3, >30, >30 and >100 μM for TRPV4, TRPV3, TRPM8 and TRPV1 respectively). Blocks TRPV4-mediated arteriole vasodilation and increases myogenic tone ex vivo.

Technical Data

M.Wt:
353.31
Formula:
C14H22CL2N2O2S
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Storage:
Store at +4°C
CAS No:
946387-07-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Vincent et al (2009) Identification and characterization of novel TRPV4 modulators. Biochem.Biophys.Res.Comms. 389 490. PMID: 19737537.

Bagher et al (2012) Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca2+ events, and IKCa channels, reducing arteriolar tone. Proc.Natl.Acad.Sci.U.S.A. 109 18174. PMID: 23071308.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: RN 1734, supplier, RN1734, selective, TRPV4, antagonists, transient, receptors, potential, channels, vanilloid

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