RN 1747

Cat. No. 3745

RN 1747 C17H18ClN3O4S [1024448-59-6]

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Chemical Name: 1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazine

Biological Activity

Selective TRPV4 agonist (EC50 values are 0.77, 4.0 and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively). Displays selectivity over other TRP channels (EC50 values are 0.77, >30, >30 and >100 μM for TRPV4, TRPM8, TRPV3 and TRPV1 receptors respectively). Also antagonizes TRPM8 at relevant concentrations (IC50 = 4 μM).

Technical Data

Soluble to 100 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Vincent et al (2009) Identification and characterization of novel TRPV4 modulators. Biochem.Biophys.Res.Comms. 389 490.

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Keywords: RN 1747, supplier, RN1747, selective, TRPV4, agonists, transient, receptors, potential, channels, vanilloid, TRPV Agonists

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