Cat. No. 3745
Chemical Name: 1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazine
Biological ActivitySelective TRPV4 agonist (EC50 values are 0.77, 4.0 and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively). Displays selectivity over other TRP channels (EC50 values are 0.77, >30, >30 and >100 μM for TRPV4, TRPM8, TRPV3 and TRPV1 receptors respectively). Also antagonizes TRPM8 at relevant concentrations (IC50 = 4 μM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Vincent et al (2009) Identification and characterization of novel TRPV4 modulators. Biochem.Biophys.Res.Comms. 389 490.
If you know of a relevant citation for this product please let us know.
Keywords: RN 1747, supplier, RN1747, selective, TRPV4, agonists, transient, receptors, potential, channels, vanilloid
Find multiple products by catalog number
New Products in this Area
TRPC1 and TRPC6 blocker; inhibits mechanosensitive ion channelsOptovin
Reversible photoactive TRPA1 activatorEIPA
Inhibits TRPP3-mediated currents; also inhibits the Na+/H+ exchanger (NHE)ML SA1
Activator of TRPML channelsPhenamil
Inhibits TRPP3-mediated currents; also inhibits epithelial Na+ channelsα-Spinasterol
TRPV1 antagonist; displays in vivo activityML 204
Selective TRPC4 blocker
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.