R&D Systems Inc. Tocris Bioscience Boston Biochem

RN 1747

Cat. No. 3745

RN 1747 C17H18ClN3O4S [1024448-59-6]

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Chemical Name: 1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazine

Biological Activity

Selective TRPV4 agonist (EC50 values are 0.77, 4.0 and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively). Displays selectivity over other TRP channels (EC50 values are 0.77, >30, >30 and >100 μM for TRPV4, TRPM8, TRPV3 and TRPV1 receptors respectively). Also antagonizes TRPM8 at relevant concentrations (IC50 = 4 μM).

Technical Data

M.Wt:
395.87
Formula:
C17H18ClN3O4S
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store at +4°C
CAS No:
1024448-59-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Vincent et al (2009) Identification and characterization of novel TRPV4 modulators. Biochem.Biophys.Res.Comms. 389 490.

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Keywords: RN 1747, supplier, RN1747, selective, TRPV4, agonists, transient, receptors, potential, channels, vanilloid

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