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RepSox

Cat. No. 3742

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Alternative Names: E-616452, SJN 2511

Chemical Name: 2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine

Biological Activity

Selective inhibitor of the TGF-β type I receptor ALK5 (IC₅₀ values are 0.004 and 0.023 μM for ALK5 autophosphorylation and ALK5 binding respectively). Selective for ALK5 over a range of kinases, including p38 MAPK, JNK1 and GSK3 (IC₅₀ > 16 μM). Enhances the efficiency of cellular reprogramming; replaces Sox2 by inducing Nanog expression.

Technical Data

M.Wt:

287.32

Formula:

C₁₇H₁₃N₅

Solubility:

Soluble to 100 mM in DMSO and to 50 mM in ethanol

Purity:

>99 %

Storage:

Store at +4°C

CAS No:

446859-33-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Gellibert et al (2004) Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-γ type I receptor inhibitors. J.Med.Chem. 47 4494. PMID: 15317461.

Ichida et al (2009) A small-molecule inhibitor of Tgf-β signaling replaces Sox2 in reprogramming by inducing Nanog. Cell Stem Cell 5 491. PMID: 19818703.

Li et al (2009) Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell Stem Cell 4 16. PMID: 19097958.

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