Cat. No. 3724
Chemical Name: N-[6-(2,6-Dichlorophenyl)-2-[[4-(di
Biological ActivitySelective FGFR inhibitor (IC50 values are 40, 262 and 3700 nM for FGFR, PDGFR and EGFR respectively). Inhibits FGFR receptor phosphorylation (IC50 = 622 nM) and growth of A121 cells in vitro.
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Hamby et al (1997) Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors. J.Med.Chem. 40 2296. PMID: 9240345.
Batley et al (1998) Inhibition of FGF-1 receptor tyrosine kinase activity by PD 161570, a new protein-tyrosine kinase inhibitor. Life Sci. 62 143. PMID: 9488112.
Stevens et al (2003) Thyroid hormone activates fibroblast growth factor receptor-1 in bone. Mol.Endocrinology 17 1751.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: PD 161570, supplier, PD161570, selective, FGFR, inhibitors, fibroblast, growth, factors, Pfizer
Find multiple products by catalog number
New Products in this Area
Potent dual Fms/KIT inhibitorBMS 599626 dihydrochloride
Potent, selective EGFR and ErbB2 inhibitorCyclotraxin B
TrkB receptor antagonistR 1530
Multi-RTK inhibitor; inhibits angiogenesis
May 2-6, 2014
Booth Number: 523