R&D Systems Inc. Tocris Bioscience Boston Biochem

Rimcazole dihydrochloride

Cat. No. 1497

Rimcazole dihydrochloride C21H27N3.2HCl [75859-03-9]

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Alternative Name: BW 234U

Chemical Name: 9-[3-(cis-3,5-Dimethyl-1-piperazinyl)propyl]-9H-carbazole dihydrochloride

Biological Activity

Antagonist at σ receptors (IC50 values are 1480 and 386 nM at σ1 and σ2 receptors respectively). Also binds to the dopamine transporter (IC50 = 57.6 nM) and inhibits dopamine uptake. Reduces the stimulatory effects of cocaine in vivo.

Technical Data

M.Wt:
394.39
Formula:
C21H27N3.2HCl
Solubility:
Soluble to 10 mM in water
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
75859-03-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Ferris et al (1986) Evidence that the potential antipsychotic agent rimcazole (BW 234U) is a specific, competitive antagonist of sigma sites in brain. Life Sci. 38 2329. PMID: 2873494.

Husbands et al (1997) Isothiocyanate derivatives of 9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]-carbazole (Rimcazole): irreversible ligands for the dopamine transporter. J.Med.Chem. 40 4340. PMID: 9435903.

Matsumoto et al (2001) Rimcazole analogs attenuate the convulsive effects of cocaine: correlation with binding to sigma receptors rather than dopamine transporters. Neuropharmacology 41 878. PMID: 11684152.

If you know of a relevant citation for this product please let us know.

Keywords: Rimcazole dihydrochloride, supplier, σ2, sigma2, antagonists, DAT, reuptake, inhibitors, Receptors, Dopamine, Transporters, Monoamine, Neurotransmitter, BW234U

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