Cat. No. 1497
Alternative Name: BW 234U
Chemical Name: 9-[3-(cis-3,5-Dimethyl-1-piperaziny
Biological ActivityAntagonist at σ receptors (IC50 values are 1480 and 386 nM at σ1 and σ2 receptors respectively). Also binds to the dopamine transporter (IC50 = 57.6 nM) and inhibits dopamine uptake. Reduces the stimulatory effects of cocaine in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Ferris et al (1986) Evidence that the potential antipsychotic agent rimcazole (BW 234U) is a specific, competitive antagonist of sigma sites in brain. Life Sci. 38 2329. PMID: 2873494.
Husbands et al (1997) Isothiocyanate derivatives of 9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]-carbazole (Rimcazole): irreversible ligands for the dopamine transporter. J.Med.Chem. 40 4340. PMID: 9435903.
Matsumoto et al (2001) Rimcazole analogs attenuate the convulsive effects of cocaine: correlation with binding to sigma receptors rather than dopamine transporters. Neuropharmacology 41 878. PMID: 11684152.
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Keywords: Rimcazole dihydrochloride, supplier, σ2, sigma2, antagonists, DAT, reuptake, inhibitors, Receptors, Dopamine, Transporters, Monoamine, Neurotransmitter, BW234U, Tocris Bioscience, σ2 Receptor Antagonists
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March 14 - 16, 2016
New Orleans, LA, USA