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Combretastatin A4

Cat No. 1495

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Alternative Names: CRC 87-09, NSC 817373

Chemical Name: 2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phe nol

Biological Activity

Antitumor, antiangiogenic and antimetastatic agent, in vitro and in vivo. Acts by inhibiting tubulin polymerization (IC₅₀ = 2 - 3 μM).

Technical Data

M.Wt:

316.35

Formula:

C₁₈H₂₀O₅

Solubility:

Soluble to 100 mM in ethanol and to 100 mM in DMSO

Purity:

>99 %

Storage:

Desiccate at -20°C

CAS No:

[117048-59-6]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

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Material Safety Data Sheet: View current batch

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References

Dorr et al (1996) Antitumor activity of combretastatin-A4 phosphate, a natural product tubulin inhibitor. Invest.New Drugs 14 131. Griggs et al (2001) Potent anti-metastatic activity of combretastatin-A4. Int.J.Oncol. 19 821. Lin et al (2007) Combretastatin A4-induced differential cytotoxicity and reduced metastatic ability by inhibition of AKT function in human gastric cancer cells. J.Pharmacol.Exp.Ther. 323 365.

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Keywords: Combretastatin A4, Inhibitor, tubulin, polymerization, Antitumor, antimetastatic, Antiangiogenics, Tau, Microtubules, Mitosis, CombretastatinA4, CRC8709