NU 7441Cat No. 3712 |
Price and AvailabilitySpecial ConditionsNo more than 50mg may be supplied to any one individual in any one year period. |
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Alternative Name: KU 57788 Chemical Name: 8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran- 4-one |
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Biological Activity
Potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (IC50 values are 14, 1700, 5000, >100000 and >100000 nM for DNA-PK, mTOR, PI 3-K, ATM and ATR respectively). Displays no activity at a range of 60 diverse kinases at 10 μM. Potentiates the effects of radiation, doxorubicin and etoposide in human tumor cell lines in vitro and etoposide in a human tumor xenograft model in vivo.Licensing Information
Sold for research purposes only under agreement from KUDOS.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Leahy et al (2004) Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries. Bioorg.Med.Chem.Letts. 14 6083. Zhao et al (2006) Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441. Cancer Res. 66 5354. Willmore et al (2008) DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia. Clin.Cancer Res. 14 3984.If you know of a useful citation for this product please let us know.
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Keywords: NU 7441, potent, selective, DNA-dependent, protein, kinases, inhibitors, Checkpoint, Control, Kinases, DNA-PK, NU7441, KU57788
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