Home » Pharmacology » Enzymes » Kinases » MAPK » JNK/c-Jun » SP 600125

SP 600125

Cat. No. 1496

Price and Availability

For SP 600125 pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: Anthra[1-9-cd]pyrazol-6(2H)-one

Biological Activity

Selective inhibitor of c-Jun N-terminal kinase (JNK). Competitively and reversibly inhibits JNK1, 2 and 3 (IC₅₀ = 40 - 90 nM) with negligible activity at ERK2, p38β and a range of enzymes (IC₅₀ > 10 μM). Active in vivo. Shown to have reduced selectivity over other protein kinases under certain conditions. Protects renal tubular epithelial cells against ischemia/reperfusion-induced apoptosis. Also available as part of the MAPK Inhibitor Tocriset™.

Technical Data

M.Wt:

220.23

Formula:

C₁₄H₈N₂O

Solubility:

Soluble to 5 mM in ethanol with gentle warming and to 100 mM in DMSO

Purity:

>98 %

Storage:

Desiccate at -20°C

CAS No:

129-56-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Select another batch:

Safety Data Sheet: View Safety Data Sheet

References

Bennett et al (2001) SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc.Natl.Acad.Sci.U.S.A. 98 13681. PMID: 11717429.

Schnabl et al (2001) TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells. Hepatology 34 953. PMID: 11679966.

Bain et al (2003) The specificities of protein kinase inhibitors: an update. Biochem.J. 371 199. PMID: 12534346.

Wang et al (2007) SP600125, a selective JNK inhibitor, protects ischemic renal injury via suppressing the extrinsic pathways of apoptosis. Life Sci. 80 2067. PMID: 17459422.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Cytokine and NF-κB Signaling JNK/c-Jun

MAPK

Keywords: SP 600125, supplier, selective, JNK, inhibitor, MAPK, Signaling, Signalling, c-Jun, N-Terminal, Kinase, SAPKs, Stress-Activated, Protein, Mitogen-Activated, SP600125

Quick Order

Find multiple products by catalog number

Cancer Research Guide

Request your free copy

Highlights over 350 products for cancer research. Request a copy or view PDF today.

Kinases Product Listing

Highlights over 350 products for kinase research. Request a copy or view PDF today.

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Some of the most potent
kinase inhibitors all on one plate

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

Immunology Guide

Highlights over 150 products for immunology research. Request a copy or view PDF today.

MAPK Signaling Review

Written by Elma Zaganjor and Melanie H. Cobb, leading experts. Request a copy or view PDF today.

Calcium Imbalance and Neuroprotective Targets

Written by E. Besancon et al

'Calcium Imbalance and Neuro-protective Targets in Cerebral Ischemia & Brain Injury' highlights the key targets involved in stroke, trauma and neurodegeneration.

MAPK Pathway

The MAPK family kinases respond to extracellular stimuli such as heat and stress to mediate intracellular signals. View pathway or download PDF today.