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N-Nonyldeoxynojirimycin

Cat No. 3691

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Alternative Name: NN-DNJ

Chemical Name: (2R,3R,4R,5S)-2-(Hydroxymethyl)-1-nonyl-3,4,5-piperidin etriol

Biological Activity

Glucosidase inhibitor (IC₅₀ values are 0.42 and 8.4 μM for acid α-glucosidase and α-1,6-glucosidase respectively). Inhibits liver glycogen breakdown in vivo. Also acts as a chemical chaperone; chaperones β-Glu folding at neutral p.H. allowing the stabilized enzyme to transit from the endoplasmic reticulum to the golgi, enabling proper trafficking to the lysosome.

Technical Data

M.Wt:

289.41

Formula:

C₁₅H₃₁NO₄

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Storage:

Store at -20°C

CAS No:

[81117-35-3]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Sawkar et al (2002) Chemical chaperones increase the cellular activity of N307S b-glucosidase: a therapeutic strategy for Gaucher disease. Proc.Natl.Acad.Sci.USA 99 15428. Andersson et al (2004) Inhibition of glycogen breakdown by imino sugars in vitro and in vivo. Biochem.Pharmacol. 67 697. Mellor et al (2004) Cellular effects of deoxyojirimycin analogues: inhibition of N-linked oligosaccharide processing and generation of free glucosylated oligosaccharides. Biochem.J. 381 867.

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Glycosylases

Keywords: N-Nonyldeoxynojirimycin, Glucosidase, inhibitors, acid, α-glucosidase, alpha-glucosidase, GAA, α-1, 6-glucosidase, alpha-1, 6-glucosidaset, a-glucosidase, glycosylases, chemical, chaperone