Bendamustine hydrochloride

Cat No. 3681

Bendamustine hydrochloride C16H21Cl2N3O2.HCl [3543-75-7]

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Chemical Name: 5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2 -butanoic acid hydrochloride

Biological Activity

Cytostatic agent that displays activity in non-Hodgkin's lymphomas. Exhibits bifunctionality; combines DNA alkylating properties with those of purine analogs.

Technical Data

M.Wt:
394.72
Formula:
C16H21Cl2N3O2.HCl
Solubility:
Soluble to 25 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
[3543-75-7]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch
Material Safety Data Sheet: View current batch

References

Schwanen et al (2002) In vitro evaluation of bendamustine induced apoptosis in B-chronic lymphocytic leukemia. Leukemia. 16 2096. Keating et al (2008) Bendamustine. Nat.Rev.Drug Discov. 7 473. Masiello and Tulpule (2009) Bendamustine therapy in chronic lymphocytic leukemia. Expert Opin.Pharmacother. 10 1687.

If you know of a useful citation for this product please let us know.

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Keywords: Bendamustine hydrochloride, Cytostatic, agent, exhibits, DNA, alkylating, purine, analogue, properties, apoptosis, inducers, dna, synthesis, inhibitors

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