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SR 3677 hydrochloride

Cat No. 3667

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Chemical Name: N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)pheny l-2,3-dihydro-1,4-benzodioxin-2-carboxamide hydrochloride

Biological Activity

Potent and selective Rho-kinase inhibitor (IC₅₀ values are 3 and 56 nM for ROCK-II and ROCK-I respectively).

Technical Data

M.Wt:

444.91

Formula:

C₂₂H₂₄N₄O₄.HCl

Solubility:

Soluble to 100 mM in water and to 100 mM in DMSO

Purity:

>98 %

Storage:

Desiccate at RT

CAS No:

[1072959-67-1]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Feng et al (2008) Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. J.Med.Chem. 51 6642.

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Keywords: SR 3677 hydrochloride, potent, selective, Rho-kinase, ROCK, inhibitors, Rho-associated, coiled-coil, kinases, stem, cells, SR3677, hydrochloride

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