GSK 4112

Cat No. 3663new product

GSK 4112 C18H21ClN2O4S

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Chemical Name: 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitr o-2-thienyl)methyl])glycinate

Biological Activity

Selective REV-ERBα agonist (EC50 = 250 nM). Enhances recruitment of nuclear receptor co-repressor (NCoR) peptide to REV-ERBα; causes acute suppression of Bmal1 gene transcription. Induces phase shifts in the circadian clock.

Technical Data

M.Wt:
396.89
Formula:
C18H21ClN2O4S
Solubility:
Soluble to 25 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch
Material Safety Data Sheet: View current batch

References

Meng et al (2008) Ligand modulation of REV-ERBalpha function resets the peripheral circadian clock in a phasic manner. J.Cell Science 121 3629.

If you know of a useful citation for this product please let us know.

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Other Nuclear Receptors

Keywords: GSK 4112, REV-ERBA, REV-ERBα, REV-ERBalpha, agonists, circadian, rhythms

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