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(-)-Indolactam V

Cat No. 3651

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Chemical Name: (2S,5S)-1,2,4,5,6,8-Hexahydro-5-(hydroxymethyl)-1-methy l-2-(1-methylethyl)-3H-pyrrolo[4,3,2-gh]-1,4-benzodiazo nin-3-one

Biological Activity

Protein kinase C activator. Exhibits tumor promoting activity. Directs differentiation of human embryonic stem cells (ESCs) into pancreatic progenitors.

Technical Data

M.Wt:

301.38

Formula:

C₁₇H₂₃N₃O₂

Solubility:

Soluble to 10 mM in DMSO

Purity:

>99 %

Storage:

Desiccate at -20°C

CAS No:

[90365-57-4]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Geiges et al (1997) Activation of protein kinase C subtypes alpha, gamma, delta, epsilon, zeta, and eta by tumor-promoting and nontumor-promoting agents. Biochem.Pharmacol. 53 865. Masuda et al (2002) Binding selectivity of conformationally restricted analogues of (-)-indolactam-V to the C1 domains of protein kinase C isozymes. Biosci.Biotechnol.Biochem. 66 1615. Chen et al (2009) A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat.Chem.Biol. 5 258.

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Keywords: (-)-Indolactam V, Protein, kinases, C, activators, PKC, (-)-IndolactamV

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