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Neuropeptide SF (mouse, rat)

Cat No. 3647

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Biological Activity

Neuropeptide FF receptor agonist (K_i values are 48.4 and 12.1 nM for NPFF₁ and NPFF₂ respectively). Potentiates the antinociceptive action of morphine in vivo and reverses the loss of morphine potency in tolerant animals. Also increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3) (EC₅₀ ~ 50 μM).

Technical Data

M.Wt:

888.03

Formula:

C₄₀H₆₅N₁₃O₁₀

Sequence:

SLAAPQRF

(Modifications: Phe-8 = C-terminal amide)

Storage:

Store at -20°C

CAS No:

[230960-31-3]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Gouarderes et al (2002) Quantitative autoradiographic distribution of NPFF₁ neuropeptide FF receptor in the rat brain and comparison with NPFF₂ receptor by using [¹²⁵I]YVP and [¹²⁵I]EYF as selective radioligands. Neurosci. 115 349. Deval et al (2003) Effects of neuropeptide SF and related peptides on acid sensing ion channel 3 and sensory neuron excitability. Neuropharmacology 44 662. Jhamandas et al (2006) Facilitation of spinal morphine analgesia in normal and morphine tolerant animals by neuropeptide SF and related peptides. Peptides 27 953.

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Keywords: Neuropeptide SF (mouse, rat), NPFF1, NPFF2, agonists, Neuropeptide, FF, AF, Receptors, FF/AF, acid, sensing, ion, channel, 3, ASIC3, NeuropeptideSF, (mouse, rat), npffr1, npffr2

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