Calyculin A

Cat. No. 1336

Calyculin A C50H81N4O15P [101932-71-2]

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Chemical Name: N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraenyl]-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propenyl]-2-oxazoly]butyl]-4-deoxy-4-(dimethylamino)-5-O-methyl-L-ribonamide

Biological Activity

Potent and selective cell-permeable inhibitor of protein phosphatase 1 (IC50 = 0.3 - 0.7 nM) and protein phosphatase 2A (IC50 = 0.5 - 1 nM). Displays > 10,000,000-fold selectivity over PP2B and PP2C.

Technical Data

M.Wt:
1009.18
Formula:
C50H81N4O15P
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
101932-71-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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References

Ishihara et al (1989) Calyculin A and okadaic acid: inhibitors of protein phosphatase activity. Biochem.Biophys.Res.Commun. 159 871. PMID: 2539153.

Favre et al (1997) Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin. J.Biol.Chem. 272 13856. PMID: 9153244.

Lindval et al (1997) The binding mode of calyculin A to protein phosphatase-1. J.Biol.Chem. 272 23312. PMID: 9287341.

McCluskey et al (2002) Serine-threonine protein phosphatase inhibitors: development of therapeutic strategies. J.Med.Chem. 45 1151. PMID: 11881984.

If you know of a relevant citation for this product please let us know.

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Keywords: Calyculin A, supplier, Protein, phosphatase, 1, 2A, inhibitors, Calcineurin, Ser/Thr, Phosphatases, PP1, PP2A, CalyculinA, Tocris Bioscience, Protein Ser/Thr Phosphatase Inhibitors

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