Cat. No. 1336
Chemical Name: N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,
Biological ActivityPotent and selective cell-permeable inhibitor of protein phosphatase 1 (IC50 = 0.3 - 0.7 nM) and protein phosphatase 2A (IC50 = 0.5 - 1 nM). Displays > 10,000,000-fold selectivity over PP2B and PP2C.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Ishihara et al (1989) Calyculin A and okadaic acid: inhibitors of protein phosphatase activity. Biochem.Biophys.Res.Commun. 159 871. PMID: 2539153.
Favre et al (1997) Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin. J.Biol.Chem. 272 13856. PMID: 9153244.
Lindval et al (1997) The binding mode of calyculin A to protein phosphatase-1. J.Biol.Chem. 272 23312. PMID: 9287341.
McCluskey et al (2002) Serine-threonine protein phosphatase inhibitors: development of therapeutic strategies. J.Med.Chem. 45 1151. PMID: 11881984.
If you know of a relevant citation for this product please let us know.
Keywords: Calyculin A, supplier, Protein, phosphatase, 1, 2A, inhibitors, Calcineurin, Ser/Thr, Phosphatases, PP1, PP2A, CalyculinA
Find multiple products by catalog number
New Products in this Area
Potent and selective allosteric inhibitor of Wip1 phosphataseVO-OHpic
Potent PTEN inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.