R&D Systems Inc. Tocris Bioscience Boston Biochem

AF-DX 384

Cat. No. 1345

AF-DX 384 C27H38N6O2 [118290-26-9]

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Chemical Name: N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide

Biological Activity

Potent M2/M4 selective antagonist (pKi values are 8.22, 8.00, 7.51, 7.18 and 6.27 at human M2, M4, M1, M3 and M5 receptors respectively).

Technical Data

M.Wt:
478.64
Formula:
C27H38N6O2
Solubility:
Soluble to 50 mM in DMSO and to 10 mM in ethanol
Purity:
>98 %
Storage:
Store at RT
CAS No:
118290-26-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Miller et al (1991) Binding of [3H]AF-DX 384 to cloned and native muscarinic receptors. J.Pharmacol.Exp.Ther. 259 601. PMID: 1941609.

Dopke et al (1995) AF-DX 384 binding in rabbit cingulate cortex: two site kinetics and section autoradiography. J.Pharmacol.Exp.Ther. 274 562. PMID: 7616446.

Grailhe et al (2009) Regional changes in the cholinergic system in mice lacking monoamine A. Brain Res.Bull. 78 283. PMID: 19111597.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: AF-DX 384, supplier, Potent, M2/M4, antagonists, Muscarinic, Receptors, Acetylcholine, ACh, AFDX384

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