BPIPPCat No. 3635 |
Price and Availability |
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Chemical Name: 5-(3-Bromophenyl)-5,11-dihydro-1,3-dimethyl-1H-indeno[2 ',1':5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione |
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Biological Activity
Non-competitive guanylyl cyclase (GC) and adenylyl cyclase (AC) inhibitor. Downregulates cAMP and cGMP synthesis, and suppresses cGMP accumulation in a variety of cell lines (IC50 = 3.4 - 11.2 μM). Inhibits GC-stimulated Cl- transport in vitro and suppresses toxin-induced intestinal fluid accumulation in vivo.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Kots et al (2008) Pyridopyrimidine derivatives as inhibitors of cyclic nucleotide synthesis: application for treatment of diarrhea. Proc.Natl.Acad.Sci.USA 105 8440.If you know of a useful citation for this product please let us know.
Keywords: BPIPP, Non-competitive, GC, inhibitors, Guanylyl, Cyclases
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