Cat. No. 3635
Chemical Name: 5-(3-Bromophenyl)-5,11-dihydro-1,3-
Biological ActivityNon-competitive guanylyl cyclase (GC) and adenylyl cyclase (AC) inhibitor. Downregulates cAMP and cGMP synthesis, and suppresses cGMP accumulation in a variety of cell lines (IC50 = 3.4 - 11.2 μM). Inhibits GC-stimulated Cl- transport in vitro and suppresses toxin-induced intestinal fluid accumulation in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Kots et al (2008) Pyridopyrimidine derivatives as inhibitors of cyclic nucleotide synthesis: application for treatment of diarrhea. Proc.Natl.Acad.Sci.USA 105 8440.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: BPIPP, supplier, Non-competitive, GC, inhibitors, Guanylyl, Cyclases
Find multiple products by catalog number
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.