R&D Systems Inc. Tocris Bioscience Boston Biochem

BPIPP

Cat. No. 3635

BPIPP C22H16BrN3O3 [325746-94-9]

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Chemical Name: 5-(3-Bromophenyl)-5,11-dihydro-1,3-dimethyl-1H-indeno[2',1':5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione

Biological Activity

Non-competitive guanylyl cyclase (GC) and adenylyl cyclase (AC) inhibitor. Downregulates cAMP and cGMP synthesis, and suppresses cGMP accumulation in a variety of cell lines (IC50 = 3.4 - 11.2 μM). Inhibits GC-stimulated Cl- transport in vitro and suppresses toxin-induced intestinal fluid accumulation in vivo.

Technical Data

M.Wt:
450.28
Formula:
C22H16BrN3O3
Solubility:
Soluble to 2 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
325746-94-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Kots et al (2008) Pyridopyrimidine derivatives as inhibitors of cyclic nucleotide synthesis: application for treatment of diarrhea. Proc.Natl.Acad.Sci.USA 105 8440.

If you know of a relevant citation for this product please let us know.

Keywords: BPIPP, supplier, Non-competitive, GC, inhibitors, Guanylyl, Cyclases

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