R&D Systems Inc. Tocris Bioscience Boston Biochem

BPIPP

Cat. No. 3635

BPIPP C22H16BrN3O3 [325746-94-9]

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Chemical Name: 5-(3-Bromophenyl)-5,11-dihydro-1,3-dimethyl-1H-indeno[2',1':5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione

Biological Activity

Non-competitive guanylyl cyclase (GC) and adenylyl cyclase (AC) inhibitor. Downregulates cAMP and cGMP synthesis, and suppresses cGMP accumulation in a variety of cell lines (IC50 = 3.4 - 11.2 μM). Inhibits GC-stimulated Cl- transport in vitro and suppresses toxin-induced intestinal fluid accumulation in vivo.

Technical Data

M.Wt:
450.28
Formula:
C22H16BrN3O3
Solubility:
Soluble to 2 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
325746-94-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Kots et al (2008) Pyridopyrimidine derivatives as inhibitors of cyclic nucleotide synthesis: application for treatment of diarrhea. Proc.Natl.Acad.Sci.USA 105 8440.

If you know of a relevant citation for this product please let us know.

Keywords: BPIPP, supplier, Non-competitive, GC, inhibitors, Guanylyl, Cyclases

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