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Lavendustin A

Cat. No. 1331

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Alternative Name: RG 14355

Chemical Name: 5-[[(2,5-Dihydroxyphenyl)methyl][(2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid

Biological Activity

Potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC₅₀ = 11 nM). Inhibits p60^c-src with an IC₅₀ of 500 nM and is selective over PKA, PKC and PI 3-kinase (IC₅₀ > 100 μM).

Technical Data

M.Wt:

381.38

Formula:

C₂₁H₁₉NO₆

Solubility:

Soluble to 25 mM in ethanol and to 25 mM in DMSO

Purity:

>98 %

Storage:

Desiccate at -20°C

CAS No:

125697-92-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Onoda et al (1989) Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus. J.Nat.Prod. 52 1252. PMID: 2614420.

Hsu et al (1991) Kinetic analysis of the inhibition of the epidermal growth factor receptor tyrosine kinase by lavendustin-A and its analogue. J.Biol.Chem. 266 21105. PMID: 1939153.

O'Dell et al (1991) Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors. Nature 353 558. PMID: 1656271.

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Keywords: Lavendustin A, supplier, EGFR, p60c-src, inhibitors, Epidermal, Growth, Factors, Receptors, ErbB, Her, Receptor, Tyrosine, Kinases, RTKs, LavendustinA, RG14355