R&D Systems Inc. Tocris Bioscience Boston Biochem

Lavendustin A

Cat. No. 1331

Lavendustin A C21H19NO6 [125697-92-9]

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Alternative Name: RG 14355

Chemical Name: 5-[[(2,5-Dihydroxyphenyl)methyl][(2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid

Biological Activity

Potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 11 nM). Inhibits p60c-src with an IC50 of 500 nM and is selective over PKA, PKC and PI 3-kinase (IC50 > 100 μM).

Technical Data

M.Wt:
381.38
Formula:
C21H19NO6
Solubility:
Soluble to 25 mM in ethanol and to 25 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
125697-92-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Onoda et al (1989) Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus. J.Nat.Prod. 52 1252. PMID: 2614420.

Hsu et al (1991) Kinetic analysis of the inhibition of the epidermal growth factor receptor tyrosine kinase by lavendustin-A and its analogue. J.Biol.Chem. 266 21105. PMID: 1939153.

O'Dell et al (1991) Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors. Nature 353 558. PMID: 1656271.

If you know of a relevant citation for this product please let us know.

Keywords: Lavendustin A, supplier, EGFR, p60c-src, inhibitors, Epidermal, Growth, Factors, Receptors, ErbB, Her, Receptor, Tyrosine, Kinases, RTKs, LavendustinA, RG14355

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