Cat. No. 1331
Alternative Name: RG 14355
Chemical Name: 5-[[(2,5-Dihydroxyphenyl)methyl][(2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid
Biological ActivityPotent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 11 nM). Inhibits p60c-src with an IC50 of 500 nM and is selective over PKA, PKC and PI 3-kinase (IC50 > 100 μM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Onoda et al (1989) Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus. J.Nat.Prod. 52 1252. PMID: 2614420.
Hsu et al (1991) Kinetic analysis of the inhibition of the epidermal growth factor receptor tyrosine kinase by lavendustin-A and its analogue. J.Biol.Chem. 266 21105. PMID: 1939153.
O'Dell et al (1991) Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors. Nature 353 558. PMID: 1656271.
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Keywords: Lavendustin A, supplier, EGFR, p60c-src, inhibitors, Epidermal, Growth, Factors, Receptors, ErbB, Her, Receptor, Tyrosine, Kinases, RTKs, LavendustinA, RG14355
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October 15, 2013