Cat. No. 1339

Anandamide C22H37NO2 [94421-68-8]

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Alternative Names: Arachidonylethanolamide, AEA

Chemical Name: N-(2-Hydroxyethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide

Biological Activity

Endogenous cannabinoid and TRPV1 receptor agonist (Ki values are 89 and 371 nM at CB1 and CB2 receptors respectively; EC50 values are 18, 31 and 27 nM at GPR55, CB1 and CB2 respectively; pKi = 5.68 for rTRPV1). Also blocks TNF-α-induced NF-κB activation via direct inhibition of IKK. Also available in water soluble emulsion (Cat. No. 1017).

Technical Data

Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)
Store at -20°C


Other Information

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet


Devane et al (1992) Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258 1946. PMID: 1470919.

Pertwee (1999) Pharmacology of cannabinoid receptor ligands. Curr.Med.Chem. 6 635. PMID: 10469884.

Ross et al (2001) Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens. Br.J.Pharmacol. 132 631. PMID: 11159715.

Sancho et al (2003) Anandamide inhibits nuclear factor-κB activation through a cannabinoid receptor-independent pathway. Mol.Pharmacol. 63 429. PMID: 12527815.

Ryberg et al (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 152 1092. PMID: 17876302.

If you know of a relevant citation for this product please let us know.

Keywords: Anandamide, supplier, Endogenous, CB, receptor, agonists, vanilloids, cannabinoids, Non-Selective, Receptors, VR1, TRPV, Channels, Transient, Receptor, Potential, cb2r, cb1r, endocannabinoids, AEA

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