Taxol

Cat. No. 1097

Taxol C47H51NO14 [33069-62-4]

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Alternative Name: Paclitaxel

Chemical Name: [2aR-[2aα,4β,4aβ,6α,9α(αR*,βS*),11α,12α,12aα,12bα]]-β-(Benzoylamino)-α-hydroxy-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester benzenepropanoic acid

Biological Activity

Antitumor agent; promotes and stabilizes tubulin polymerization, causing cell cycle arrest. Induces autocatalytic activation of caspase-10 in CCRF-HSB-2 cells, triggering apoptosis.

Technical Data

M.Wt:
853.92
Formula:
C47H51NO14
Solubility:
Soluble to 25 mM in ethanol and to 100 mM in DMSO with gentle warming
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
33069-62-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Merck Index 12 7117.

McGuire et al (1989) Taxol: a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms. Ann.Intern.Med. 111 273. PMID: 2569287.

Rowinsky et al (1990) Taxol: a novel investigational antimicrotubule agent. J.Natl.Cancer Inst. 82 1247. PMID: 1973737.

Rao et al (1999) Characterization of the taxol binding site on the microtubule. J.Biol.Chem. 274 37990. PMID: 10608867.

Park et al (2004) Taxol induces caspase-10-dependent apoptosis. J.Biol.Chem. 279 51057. PMID: 15452117.

If you know of a relevant citation for this product please let us know.

View Related Products by Product Action

Keywords: Taxol, supplier, Promotes, assembly, inhibits, inhibitor, disassembly, microtubules, Tau, Tubulin, Mitosis, taxanes, Tocris Bioscience, Microtubules

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