Cat. No. 1097
Alternative Name: Paclitaxel
Chemical Name: [2aR-[2aα,4β,4aβ,6α,9α(αR*,βS*),11α,12α,12aα,
Biological ActivityAntitumor agent; promotes and stabilizes tubulin polymerization, causing cell cycle arrest. Induces autocatalytic activation of caspase-10 in CCRF-HSB-2 cells, triggering apoptosis.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Merck Index 12 7117.
McGuire et al (1989) Taxol: a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms. Ann.Intern.Med. 111 273. PMID: 2569287.
Rowinsky et al (1990) Taxol: a novel investigational antimicrotubule agent. J.Natl.Cancer Inst. 82 1247. PMID: 1973737.
Rao et al (1999) Characterization of the taxol binding site on the microtubule. J.Biol.Chem. 274 37990. PMID: 10608867.
Park et al (2004) Taxol induces caspase-10-dependent apoptosis. J.Biol.Chem. 279 51057. PMID: 15452117.
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Keywords: Taxol, supplier, Promotes, assembly, inhibits, inhibitor, disassembly, microtubules, Tau, Tubulin, Mitosis, taxanes
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