R&D Systems Inc. Tocris Bioscience Boston Biochem

Taxol

Cat. No. 1097

Taxol C47H51NO14 [33069-62-4]

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Alternative Name: Paclitaxel

Chemical Name: [2aR-[2aα,4β,4aβ,6α,9α(αR*,βS*),11α,12α,12aα,12bα]]-β-(Benzoylamino)-α-hydroxy-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester benzenepropanoic acid

Biological Activity

Antitumor agent; promotes and stabilizes tubulin polymerization, causing cell cycle arrest. Induces autocatalytic activation of caspase-10 in CCRF-HSB-2 cells, triggering apoptosis.

Technical Data

M.Wt:
853.92
Formula:
C47H51NO14
Solubility:
Soluble to 25 mM in ethanol and to 100 mM in DMSO with gentle warming
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
33069-62-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Merck Index 12 7117.

McGuire et al (1989) Taxol: a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms. Ann.Intern.Med. 111 273. PMID: 2569287.

Rowinsky et al (1990) Taxol: a novel investigational antimicrotubule agent. J.Natl.Cancer Inst. 82 1247. PMID: 1973737.

Rao et al (1999) Characterization of the taxol binding site on the microtubule. J.Biol.Chem. 274 37990. PMID: 10608867.

Park et al (2004) Taxol induces caspase-10-dependent apoptosis. J.Biol.Chem. 279 51057. PMID: 15452117.

If you know of a relevant citation for this product please let us know.

Keywords: Taxol, supplier, Promotes, assembly, inhibits, inhibitor, disassembly, microtubules, Tau, Tubulin, Mitosis, taxanes

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