R&D Systems Inc. Tocris Bioscience Boston Biochem

Camptothecin

Cat. No. 1100

Camptothecin C20H16N2O4 [7689-03-4]

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Chemical Name: (S)-4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

Biological Activity

Cytotoxic plant alkaloid with antitumor properties; prototypic DNA topoisomerase I inhibitor. Induces single strand DNA breaks and protein-DNA crosslinks.

Technical Data

M.Wt:
348.36
Formula:
C20H16N2O4
Solubility:
Soluble to 5 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
7689-03-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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References

Merck Index 12 1783.

Hsiang et al (1985) Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J.Biol.Chem. 260 14873. PMID: 2997227.

Liu (1989) DNA topoisomerase poisons as antitumour drugs. Annu.Rev.Biochem 58 351. PMID: 2549853.

Pantazis et al (1993) Camptothecin derivatives induce regression of human ovarian carcinomas grown in nude mice and distinguish between non-tumorigenic and tumorigenic cells in vitro. Int.J.Cancer 53 863. PMID: 8449612.

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Keywords: Camptothecin, supplier, DNA, topoisomerases, inhibitors, Isomerases

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