R&D Systems Inc. Tocris Bioscience Boston Biochem

Camptothecin

Cat. No. 1100

Camptothecin C20H16N2O4 [7689-03-4]

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Chemical Name: (S)-4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

Biological Activity

Cytotoxic plant alkaloid with antitumor properties; prototypic DNA topoisomerase I inhibitor. Induces single strand DNA breaks and protein-DNA crosslinks.

Technical Data

M.Wt:
348.36
Formula:
C20H16N2O4
Solubility:
Soluble to 5 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
7689-03-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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References

Merck Index 12 1783.

Hsiang et al (1985) Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J.Biol.Chem. 260 14873. PMID: 2997227.

Liu (1989) DNA topoisomerase poisons as antitumour drugs. Annu.Rev.Biochem 58 351. PMID: 2549853.

Pantazis et al (1993) Camptothecin derivatives induce regression of human ovarian carcinomas grown in nude mice and distinguish between non-tumorigenic and tumorigenic cells in vitro. Int.J.Cancer 53 863. PMID: 8449612.

If you know of a relevant citation for this product please let us know.

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Keywords: Camptothecin, supplier, DNA, topoisomerases, inhibitors, Isomerases

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