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Ketoconazole

Cat. No. 1103

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Chemical Name: cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl] methoxy]phenyl]piperazine

Biological Activity

Antifungal agent; potent inhibitor of cytochrome P450c17.

Technical Data

M.Wt:

531.44

Formula:

C₂₆H₂₈Cl₂N₄O₄

Solubility:

Soluble to 50 mM in ethanol and to 75 mM in DMSO

Purity:

>99 %

Storage:

Desiccate at +4°C

CAS No:

65277-42-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Merck Index 12 5313.

Ayub and Levell (1989) Inhibition of human adrenal steroidogenic enzymes in vitro by imidazole drugs including ketoconazole. J.Steroid Biochem. 32 515. PMID: 2724954.

Kuhn-Velten et al (1992) Ketoconazole inhibition of the bifunctional cytochrome P450c17 does not affect androgen formation from the endogenous lyase substrate. Biochem.Pharmacol. 44 2371. PMID: 1472102.

Dumaine et al (1998) Blockade of HERG and Kv1.5 by ketoconazole. J.Pharmacol.Exp.Ther. 286 727. PMID: 9694927.

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