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LY 311727

Cat No. 3627

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Chemical Name: [3-[[3-(2-Amino-2-oxoethyl)-2-ethyl-1-(phenylmethyl)-1H -indol-5-yl]oxy]propyl]-phosphonic acid

Biological Activity

Selective secreted phospholipase A₂ (sPLA₂) inhibitor (IC₅₀ values are <1 μM for group IIA and <50 μM for group V). Attenuates VEGF-mediated platelet-activating factor (PAF) synthesis in BAEC and HUVEC cells at a concentration of 100 μM.

Technical Data

M.Wt:

430.43

Formula:

C₂₂H₂₇N₂O₅P

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in 1eq. NaOH

Purity:

>98 %

Storage:

Store at +4°C

CAS No:

[164083-84-5]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Schevitz et al (1995) Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2. Nat.Struct.Biol. 2 429. Bridonneau et al (1997) High-affinity aptamers selectively inhibit human nonpancreatic secretory phospholipase A₂ (hnps-PLA₂) J.Med.Chem. 41 778. Bernatchez et al (2001) VEGF stimulation of endothelial cell PAF synthesis is mediated by group V 14 kDa secretory phospholipase A₂. Br.J.Pharmacol. 134 197.

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