Vincristine sulfate

Cat. No. 1257

Vincristine sulfate C46H56N4O10.H2SO4 [2068-78-2]

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Chemical Name: 22-Oxovincaleukoblastine

Biological Activity

Anticancer agent; microtubule disrupter. Induces apoptosis in human lymphoma cells.

Technical Data

M.Wt:
923.04
Formula:
C46H56N4O10.H2SO4
Solubility:
Soluble to 100 mM in water
Purity:
>96 %
Storage:
Desiccate at +4°C
CAS No:
2068-78-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Jordan et al (1985) Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res. 45 2741. PMID: 3986806.

Takano et al (1993) Apoptosis induced by microtubule disrupting drugs in cultured human lymphoma cells. Inhibitory effects of phorbol ester and zinc sulphate. Pathol.Res.Pract. 189 197. PMID: 8321748.

Wang et al (1999) The effect of antimicrotubule agents on signal transduction pathways of apoptosis. Cancer Chemother.Pharmacol. 44 355. PMID: 10501907.

If you know of a relevant citation for this product please let us know.

Keywords: Vincristine sulfate, supplier, Disrupts, microtubules, Tau, Tubulin, Mitosis

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