Cat. No. 1256
Chemical Name: Vincaleukoblastine
Biological ActivityAnticancer agent; microtubule disrupter. Induces apoptosis in cultured hepatocytes and human lymphoma cells. Shown to inhibit autophagosome maturation.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Jordan et al (1985) Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res. 45 2741. PMID: 3986806.
Tsukidate et al (1993) Microtubule antagonists activate programmed cell death (apoptosis) in cultured rat hepatocytes. Am.J.Pathol. 143 918. PMID: 8362985.
Rai and Wolf (1998) Localization of critical histidyl residues required for vinblastine-induced tubulin polymerization and for microtubulin assembly. J.Biol.Chem. 273 31131. PMID: 9813016.
Veldhoen et al (2012) The chemotherapeutic agent paclitaxel inhibits autophagy through two distinct mechanisms that regulate apoptosis. Oncogene 32 736. PMID: 22430212.
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Keywords: Vinblastine sulfate, supplier, Disrupts, microtubules, Mitosis, Tau, Tubulin