Vinblastine sulfate

Cat. No. 1256

Vinblastine sulfate C46H58N4O9.H2SO4 [143-67-9]

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Chemical Name: Vincaleukoblastine

Biological Activity

Anticancer agent; microtubule disrupter. Induces apoptosis in cultured hepatocytes and human lymphoma cells. Shown to inhibit autophagosome maturation.

Technical Data

M.Wt:
909.06
Formula:
C46H58N4O9.H2SO4
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>95 %
Storage:
Desiccate at +4°C
CAS No:
143-67-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Jordan et al (1985) Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res. 45 2741. PMID: 3986806.

Tsukidate et al (1993) Microtubule antagonists activate programmed cell death (apoptosis) in cultured rat hepatocytes. Am.J.Pathol. 143 918. PMID: 8362985.

Rai and Wolf (1998) Localization of critical histidyl residues required for vinblastine-induced tubulin polymerization and for microtubulin assembly. J.Biol.Chem. 273 31131. PMID: 9813016.

Veldhoen et al (2012) The chemotherapeutic agent paclitaxel inhibits autophagy through two distinct mechanisms that regulate apoptosis. Oncogene 32 736. PMID: 22430212.

If you know of a relevant citation for this product please let us know.

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Keywords: Vinblastine sulfate, supplier, Disrupts, microtubules, Mitosis, Tau, Tubulin, Tocris Bioscience, Microtubules

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