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Enterostatin

Cat. No. 3612

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Biological Activity

N' terminal peptide fragment of procolipase that binds to the β-subunit of F1-ATPase. Activates the ERK and cAMP signaling pathways, and downregulates expression of Krüppel-like factor 4 (KLF4) and agouti-related peptide (AgRP) in vitro. Inhibits insulin secretion from pancreatic β-cells by downregulating expression of dynamin2 and altering protein trafficking. Reduces dietary fat intake via activation of CCK₁, induces satiety, enhances memory-consolidation and exhibits hypocholesterolemic activity in vivo. Orally active.

Technical Data

M.Wt:

496.57

Formula:

C₂₁H₃₆N₈O₆

Sequence:

APGPR

Solubility:

Soluble to 0.70 mg/ml in water

Storage:

Store at -20°C

CAS No:

117830-79-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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References

Takenaka et al (2008) Enterostatin reduces serum cholesterol levels by way of a CCK(1) receptor-dependent mechanism. Peptides 29 2175. PMID: 18824202.

Park et al (2009) Enterostatin affects cyclic AMP and ERK signaling pathways to regulate Agouti-related Protein (AgRP) expression. Peptides 30 181. PMID: 19059445.

Park et al (2009) Enterostatin alters protein trafficking to inhibit insulin secretion in Beta-TC6 cells. Peptides 30 1866. PMID: 19563849.

If you know of a relevant citation for this product please let us know.

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Keywords: Enterostatin, supplier, Binds, β-subunit, beta-subunit, F1-ATPase, anorexigenic, peptide, activators, CCK1, reduces, dietary, fat, intake, P-Type, ATPase, V-Type, E-Type, F-Type, ATPases, GTPases, Oxidative, phosphorylation, Cholecystokinin1, Receptors, CCK, Cholecystokinin

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