Cat. No. 3612
Biological ActivityN' terminal peptide fragment of procolipase that binds to the β-subunit of F1-ATPase. Activates the ERK and cAMP signaling pathways, and downregulates expression of Krüppel-like factor 4 (KLF4) and agouti-related peptide (AgRP) in vitro. Inhibits insulin secretion from pancreatic β-cells by downregulating expression of dynamin2 and altering protein trafficking. Reduces dietary fat intake via activation of CCK1, induces satiety, enhances memory-consolidation and exhibits hypocholesterolemic activity in vivo. Orally active.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Takenaka et al (2008) Enterostatin reduces serum cholesterol levels by way of a CCK(1) receptor-dependent mechanism. Peptides 29 2175. PMID: 18824202.
Park et al (2009) Enterostatin affects cyclic AMP and ERK signaling pathways to regulate Agouti-related Protein (AgRP) expression. Peptides 30 181. PMID: 19059445.
Park et al (2009) Enterostatin alters protein trafficking to inhibit insulin secretion in Beta-TC6 cells. Peptides 30 1866. PMID: 19563849.
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Keywords: Enterostatin, supplier, Binds, β-subunit, beta-subunit, F1-ATPase, anorexigenic, peptide, activators, CCK1, reduces, dietary, fat, intake, P-Type, ATPase, V-Type, E-Type, F-Type, ATPases, GTPases, Oxidative, phosphorylation, Cholecystokinin1, Receptors, CCK, Cholecystokinin
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