Cat. No. 3610
Chemical Name: 2-[[9-(1-Methylethyl)-6-[[3-(2-pyri
Biological ActivityPotent, ATP-competitive inhibitor of cyclin-dependent kinase (cdk) and casein kinase 1 (CK1) (IC50 values are 220, 80 and 14 nM for cdk1/cyclin B, cdk5/p25 and CK1 respectively). Selective over GSK-3 αβ (IC50= 4.1 μM). Also shown to inhibit amyloid-β production in N2A-APP695 cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Oumata et al (2008) Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1. J.Med.Chem. 51 522.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: (R)-DRF053 dihydrochloride, supplier, casein, cyclin-dependent, kinases, cyclin, cdk5, cdk1, CK1, p25, dual, specificity, inhibits, inhibitors
Find multiple products by catalog number
New Products in this Area
CK1 inhibitorT 5601640
Selective LIMK2 inhibitor; antitumor3PO
PFKFB3 inhibitor; antiangiogenicCHR 6494 trifluoroacetate
Potent and selective haspin kinase inhibitorUNC 3230
Potent and selective PIP5K1C inhibitor; antinociceptivetrans-ISRIB
Integrated stress response (ISR) inhibitortrans-ISRIB
Integrated stress response (ISR) inhibitorBMS 509744
Potent and selective ITK inhibitorWZ 4003
Potent and selective NUAK1/2 inhibitorTC-S 7010
Potent and selective Aurora kinase A inhibitorBryostatin 2
Protein kinase C activatorZLN 024 hydrochloride
Allosteric AMPK activatorTemsirolimus
mTOR inhibitor; antitumorKN 93 phosphate
CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278).ETP 45835 dihydrochloride
Mnk1 and Mnk2 inhibitorBryostatin 3
Potent protein kinase C activatorGKA 50
April 12 - 15, 2015