R&D Systems Inc. Tocris Bioscience Boston Biochem

(R)-DRF053 dihydrochloride

Cat. No. 3610

(R)-DRF053 dihydrochloride C23H27N7O.2HCl [1241675-76-2]

Price and Availability

For (R)-DRF053 dihydrochloride pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 2-[[9-(1-Methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]-9H-purin-2-yl]amino]-1-butanol dihydrochloride

Biological Activity

Potent, ATP-competitive inhibitor of cyclin-dependent kinase (cdk) and casein kinase 1 (CK1) (IC50 values are 220, 80 and 14 nM for cdk1/cyclin B, cdk5/p25 and CK1 respectively). Selective over GSK-3 αβ (IC50= 4.1 μM). Also shown to inhibit amyloid-β production in N2A-APP695 cells.

Technical Data

M.Wt:
490.43
Formula:
C23H27N7O.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1241675-76-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

Oumata et al (2008) Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1. J.Med.Chem. 51 522.

If you know of a relevant citation for this product please let us know.

Keywords: (R)-DRF053 dihydrochloride, supplier, casein, cyclin-dependent, kinases, cyclin, cdk5, cdk1, CK1, p25, dual, specificity, inhibits, inhibitors

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Guide

Highlights over 350 products for cancer research. Request a copy or view PDF today.

divider line

Kinases Product Listing

Kinases Product Listing

Highlights over 350 products for kinase research. Request a copy or view PDF today.

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Some of the most potent
kinase inhibitors all on one plate

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

New Product Guide

NPG

Highlights over 130 new products added in the second half of 2013. Request a copy or view PDF today.

divider line

New Products in this Area

PS 1145 dihydrochloride

Selective IKK inhibitor; orally active

RSVA 405

AMPK activator

Atiprimod dihydrochloride

JAK2 Inhibitor

AIM 100

Potent and selective Ack1 inhibitor

ML 120B dihydrochloride

Novel IKK2-selective inhibitor

ML 202

Pyruvate kinase M2 activator

GNF 5

Selective allosteric inhibitor of Bcr-Abl; analog of GNF 2 (Cat. No. 4399)

TC-S 7005

Potent and selective PLK2 inhibitor

SRPIN340

Selective SRPK1 inhibitor

TC-S 7003

Potent Lck inhibitor

ML 281

STK33 inhibitor

CRT 0066101

Potent protein kinase D (PKD) inhibitor

Harmine

Potent and selective Dyrk1A inhibitor

AZ 628

Potent Raf kinase inhibitor

CHIR 99021 trihydrochloride

Hydrochloride salt of CHIR 99021 (Cat. No. 4423); selective GSK-3 inhibitor

YZ9

PFKFB3 inhibitor; inhibits cell growth

KU 0060648

Dual DNA-PK and PI 3-K inhibitor

KB SRC 4

Potent and selective c-Src inhibitor

Sign-up for new product e-alerts
divider line

Tocris Events

Immunology 2014

Immunology 2014

May 2-6, 2014

Pittsburgh, Pennsylvania

Booth Number: 523