Home » Pharmacology » Nuclear Receptors » Estrogen Receptors » ICI 182,780

ICI 182,780

Cat. No. 1047

Price and Availability

For ICI 182,780 pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Special Conditions

No more than 1 g per customer per year to be sold.

Chemical Name: 7α,17β-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol

Biological Activity

A high affinity estrogen receptor antagonist (IC₅₀ = 0.29 nM), devoid of any partial agonism both in vitro and in vivo. Also high affinity agonist at the membrane estrogen receptor GPR30.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M.Wt:

606.77

Formula:

C₃₂H₄₇F₅O₃S

Solubility:

Soluble to 50 mM in ethanol and to 100 mM in DMSO

Purity:

>99 %

Storage:

Store at RT

CAS No:

129453-61-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Select another batch:

Safety Data Sheet: View Safety Data Sheet

References

Wakeling et al (1991) A potent specific pure antiestrogen with clinical potential. Cancer Res. 51 3867. PMID: 1855205.

de Cupis et al (1995) Comparison between novel steroid-like and conventional nonsteroidal antioestrogens in inhibiting oestradiol and IGF-I induced proliferation of human breast cancer-derived cells. Br.J.Pharmacol. 116 2391. PMID: 8581274.

Howell et al (2000) ICI 182,780 (Faslodex^TM): Development of a novel, "pure" antiestrogen. Cancer 89 817. PMID: 10951345.

Thomas et al (2005) Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology. 146 624. PMID: 15539556.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Estrogen (GPR30) Receptors

Estrogen Receptors

Keywords: ICI 182,780, supplier, High, affinity, GPR30, agonist, Estrogen, receptors, antagonists, ER, ERR, ICI182780, AstraZeneca

Quick Order

Find multiple products by catalog number

Cancer Research Guide

Request your free copy

Highlights over 350 products for cancer research. Request a copy or view PDF today.

Estrogen Pathway

Estrogen controls many cellular processes including growth, differentiation and function of the reproductive system. View pathway or download PDF today.