R&D Systems Inc. Tocris Bioscience Boston Biochem

SU 3327

Cat. No. 3607

SU 3327 C5H3N5O2S3 [40045-50-9]

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Chemical Name: 5-[(5-Nitro-2-thiazolyl)thio]-1,3,4thiadiazol-2-amine

Biological Activity

Selective inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 0.7 μM). Inhibits the protein-protein interaction between JNK and JIP (IC50 = 239 nM). Displays selectivity over p38 MAPK and Akt. Restores insulin sensitivity in a mouse model of type-2 diabetes.

Technical Data

M.Wt:
261.3
Formula:
C5H3N5O2S3
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
40045-50-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

De et al (2009) Design, synthesis and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-jun N-terminal kinase. J.Med.Chem. 52 1943. PMID: 19271755.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: SU 3327, supplier, SU3327, JNK, kinases, inhibitors, selective, MAPK, Signaling, Signalling, c-Jun, N-Terminal, SAPKs, Stress-Activated, Protein, Mitogen-Activated

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