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SU 3327

Cat. No. 3607

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Chemical Name: 5-[(5-Nitro-2-thiazolyl)thio]-1,3,4thiadiazol-2-amine

Biological Activity

Selective inhibitor of c-Jun N-terminal kinase (JNK) (IC₅₀ = 0.7 μM). Inhibits the protein-protein interaction between JNK and JIP (IC₅₀ = 239 nM). Displays selectivity over p38 MAPK and Akt. Restores insulin sensitivity in a mouse model of type-2 diabetes.

Technical Data

M.Wt:

261.3

Formula:

C₅H₃N₅O₂S₃

Solubility:

Soluble to 100 mM in DMSO and to 10 mM in ethanol

Purity:

>99 %

Storage:

Store at RT

CAS No:

40045-50-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

De et al (2009) Design, synthesis and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-jun N-terminal kinase. J.Med.Chem. 52 1943. PMID: 19271755.

If you know of a relevant citation for this product please let us know.

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