(R)-CR8

Cat. No. 3605

(R)-CR8 C24H29N7O.3HCl [294646-77-8]

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Chemical Name: 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurine trihydrochloride

Biological Activity

Inhibitor of cyclin-dependent kinase (cdk) and casein kinase 1 (CK1) (IC50 values are 0.13 μM for cdk1/cyclin B and cdk5/p25; and 0.6 μM for CK1).

Technical Data

M.Wt:
540.92
Formula:
C24H29N7O.3HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
294646-77-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Oumata et al (2008) Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1. J.Med.Chem. 51 5229. PMID: 18698753.

If you know of a relevant citation for this product please let us know.

View Related Products by Product Action

Keywords: (R)-CR8, supplier, cdk1, cdk5, inhibitors, inhibits, CK1, cyclin-dependent, kinases, casein, kinase, 1, Tocris Bioscience, Cyclin-Dependent Protein Kinase Inhibitors

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