Cat. No. 3603
Alternative Name: Kempferol
Chemical Name: 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Biological ActivityNaturally occurring flavonoid found in Gingko biloba and red wines that activates the mitochondrial Ca2+ uniporter (EC50 = 7 μM). Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Montero et al (2004) Direct activation of the mitochondrial calcium uniporter by natural plant flavonoids. Biochem.J. 384 19. PMID: 15324303.
Kang et al (2009) Downregulation of PLK-1 expression in kaempferol-induced apoptosis of MCF-7 cells. Eur.J.Pharmacol. 611 17. PMID: 19356725.
Suh et al (2009) Kaempferol attenuates 2-deoxy-D-ribose-induced oxidative cell damage in MC3T3-E1 osteoblastic cells. Biol.Pharm.Bull. 32 746. PMID: 19336918.
Vay et al (2009) Modulation of Ca2+ release and Ca2+ oscillations in HeLa cells and fibroblasts by mitochondrial Ca2+ uniporter stimulation. J.Physiol. 580 39.
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Keywords: Kaempferol, supplier, Mitochondrial, Ca2+, uniporter, MCU, activators, proapoptotic, downregulates, PLK1, expression, Ion, Pumps, Transporters, Apoptosis, Inducer
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