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Kaempferol

Cat. No. 3603

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Alternative Name: Kempferol

Chemical Name: 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Biological Activity

Naturally occurring flavonoid found in Gingko biloba and red wines that activates the mitochondrial Ca²⁺ uniporter (EC₅₀ = 7 μM). Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro.

Technical Data

M.Wt:

286.24

Formula:

C₁₅H₁₀O₆

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

>98 %

Storage:

Store at +4°C

CAS No:

520-18-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Montero et al (2004) Direct activation of the mitochondrial calcium uniporter by natural plant flavonoids. Biochem.J. 384 19. PMID: 15324303.

Kang et al (2009) Downregulation of PLK-1 expression in kaempferol-induced apoptosis of MCF-7 cells. Eur.J.Pharmacol. 611 17. PMID: 19356725.

Suh et al (2009) Kaempferol attenuates 2-deoxy-D-ribose-induced oxidative cell damage in MC3T3-E1 osteoblastic cells. Biol.Pharm.Bull. 32 746. PMID: 19336918.

Vay et al (2009) Modulation of Ca²⁺ release and Ca²⁺ oscillations in HeLa cells and fibroblasts by mitochondrial Ca²⁺ uniporter stimulation. J.Physiol. 580 39.

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Keywords: Kaempferol, supplier, Mitochondrial, Ca2+, uniporter, MCU, activators, proapoptotic, downregulates, PLK1, expression, Ion, Pumps, Transporters, Apoptosis, Inducer

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