Cat. No. 1035
Chemical Name: 8-Methoxy-2-propionamidotetralin
Biological ActivityMelatonin receptor agonist, 20-fold selective for the MT2 (vs MT1) subtype. At human recombinant MT1 and MT2 receptors, displays pKi values of 8.23 and 8.95 respectively.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Dubocovich et al (1995) Melatonin receptors: are there multiple subtypes? TiPS 16 50. PMID: 7762083.
Dubocovich et al (1997) Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroceptor. Naunyn Schmiedebergs Arch.Pharmacol. 355 365. PMID: 9089668.
Browning et al (2000) Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptors. Br.J.Pharmacol. 129 877. PMID: 10696085.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: 8-M-PDOT, supplier, Melatonin, agonists, Receptors, MT, 8MPDOT
Find multiple products by catalog number
New Products in this Area
P2Y12 inhibitorRactopamine hydrochloride
Trace amine 1 (TA1) receptor agonistTG 4-155
High affinity and selective EP2 receptor antagonistSAG
Potent Smoothened receptor agonist; activates the Hedgehog signaling pathwayDC 260126
FFA1 (GPR40) antagonistAR-C 118925XX
Selective, competitive P2Y2 receptor antagonistEPPTB
Trace amine 1 (TA1) receptor antagonist/inverse agonistNIBR 189
Potent and selective EBI2 (GPR183) receptor antagonist
May 19 - 22, 2015