Cat. No. 1035

8-M-PDOT C14H19NO2 [134865-70-6]

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Chemical Name: 8-Methoxy-2-propionamidotetralin

Biological Activity

Melatonin receptor agonist, 20-fold selective for the MT2 (vs MT1) subtype. At human recombinant MT1 and MT2 receptors, displays pKi values of 8.23 and 8.95 respectively.

Technical Data

Soluble to 50 mM in ethanol and to 100 mM in DMSO
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Dubocovich et al (1995) Melatonin receptors: are there multiple subtypes? TiPS 16 50. PMID: 7762083.

Dubocovich et al (1997) Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroceptor. Naunyn Schmiedebergs Arch.Pharmacol. 355 365. PMID: 9089668.

Browning et al (2000) Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptors. Br.J.Pharmacol. 129 877. PMID: 10696085.

If you know of a relevant citation for this product please let us know.

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Keywords: 8-M-PDOT, supplier, Melatonin, agonists, Receptors, MT, 8MPDOT, Melatonin Receptor Agonists

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