8-M-PDOT

Cat. No. 1035

8-M-PDOT C14H19NO2 [134865-70-6]

Price and Availability

For 8-M-PDOT pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 8-Methoxy-2-propionamidotetralin

Biological Activity

Melatonin receptor agonist, 20-fold selective for the MT2 (vs MT1) subtype. At human recombinant MT1 and MT2 receptors, displays pKi values of 8.23 and 8.95 respectively.

Technical Data

M.Wt:
233.31
Formula:
C14H19NO2
Solubility:
Soluble to 50 mM in ethanol and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
134865-70-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Dubocovich et al (1995) Melatonin receptors: are there multiple subtypes? TiPS 16 50. PMID: 7762083.

Dubocovich et al (1997) Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroceptor. Naunyn Schmiedebergs Arch.Pharmacol. 355 365. PMID: 9089668.

Browning et al (2000) Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptors. Br.J.Pharmacol. 129 877. PMID: 10696085.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: 8-M-PDOT, supplier, Melatonin, agonists, Receptors, MT, 8MPDOT

Quick Order

Find multiple products by catalog number

divider line

New Product E-alerts

Sign up for email updates from Tocris

e-alerts

Enter your email address below to sign up to receive our email updates:

divider line

New Products in this Area

IHR 1

Potent Smo antagonist

ONO 8130

EP1 receptor antagonist

TC-G 1008

Potent and selective GPR39 agonist

Ro 1138452 hydrochloride

Selective prostacyclin IP receptor antagonist

JNJ 27141491

Potent and selective human CCR2 antagonist

TY 52156

S1P3 receptor antagonist

Elinogrel

P2Y12 antagonist

Ractopamine hydrochloride

Trace amine 1 (TA1) receptor agonist

Sign-up for new product e-alerts
divider line

Bio-Techne Events

ESM 2015

5th European Synapse Meeting

September 7 - 9, 2015

Bristol, UK