Cat. No. 3600
Chemical Name: N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzi
Biological ActivityPotent phosholipase D (PLD) inhibitor (IC50 values are 20 and 25 nM for PLD2 and PLD1 respectively). Ameliorates PLD2-driven suppression of membrane ruffling and cell spreading. Orally available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Monovich et al (2007) Optimization of halopemide for phospholipase D2 inhibition. Bioorg.Med.Chem.Lett. 17 2310. PMID: 17317170.
Su et al (2009) 5-fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. Mol.Pharmcol. 75 43.
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Keywords: FIPI, supplier, potent, phospholipases, D, PLD1, PLD2, inhibitors, inhibits, esterases