R&D Systems Inc. Tocris Bioscience Boston Biochem

FIPI

Cat. No. 3600

FIPI C23H24FN5O2.HCl [939055-18-2]

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Chemical Name: N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethy]-5-fluoro-1H-indole-2-carboxamide hydrochloride

Biological Activity

Potent phosholipase D (PLD) inhibitor (IC50 values are 20 and 25 nM for PLD2 and PLD1 respectively). Ameliorates PLD2-driven suppression of membrane ruffling and cell spreading. Orally available.

Technical Data

M.Wt:
457.93
Formula:
C23H24FN5O2.HCl
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
939055-18-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Monovich et al (2007) Optimization of halopemide for phospholipase D2 inhibition. Bioorg.Med.Chem.Lett. 17 2310. PMID: 17317170.

Su et al (2009) 5-fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. Mol.Pharmcol. 75 43.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: FIPI, supplier, potent, phospholipases, D, PLD1, PLD2, inhibitors, inhibits, esterases

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