Cat. No. 3599
Alternative Name: Mubritinib
Chemical Name: 1-[4-[4-[[2-[(1E)-2-[4-(trifluorome
Biological ActivityPotent, irreversible human epithelial growth factor receptor 2 (ErbB2) inhibitor (IC50 = 6 nM) that displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src. Exhibits potent antiproliferative effects in ErbB2-overexpressing cancer cell lines (IC50 = 5 nM in BT474 breast cancer cells) and significantly inhibits bladder, breast and prostate cancer xenograft growth in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Sridhar et al (2003) Inhibitors of epidermal-growth-factor receptors: a review of clinical research with a focus on non-small-cell lung cancer. Lancet Oncol. 4 397. PMID: 12850190.
Nagasawa et al (2006) Novel HER2 selective tyrosine kinase inhibitor, TAK-165, inhibits bladder, kidney and androgen-independent prostate cancer in vitro and in vivo. Int.J.Urol. 13 585.
Spector et al (2007) Small molecule HER-2 tyrosine kinase inhibitors. Breast Cancer Res. 9 205.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: TAK 165, supplier, Potent, selective, ErbB2, inhibitors, Epidermal, Growth, Factor, Receptors, Her, EGFR, Receptor, Tyrosine, Kinases, RTKs, TAK165
Find multiple products by catalog number
New Products in this Area
Potent anaplastic lymphoma kinase (ALK) inhibitorKYL
EphA4 receptor tyrosine kinase antagonist; neuroprotectivePD 90780
Inhibits NGF binding to p75NTRLM11A 31 dihydrochloride
Nonpeptide p75NTR ligand; neuroprotectiveEG 00229
Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1Toceranib
Potent PDGFR and VEGFR inhibitorNVP ADW 742
ATP-competitive inhibitor of IGF1R
One Day Symposium
March 17, 2015