L-741,626Cat No. 1003 |
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Chemical Name: 3-[[4-(4-Chlorophenyl)-4-hydroxypiperidin-l-yl]methyl-1 H-indole |
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Biological Activity
A potent D2 dopamine receptor selective antagonist, with affinities of 2.4, 100 and 220 nM for D2 , D3 and D4 receptors respectively. Centrally active following systemic administration in vivo.Licensing Information
Sold with the permission of Merck Sharp and Dohme Ltd.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Kulagowski et al (1996) 3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor. J.Med.Chem. 39 1941. Bowery et al (1996) Antagonism of the effects of (+)-PD 128907 on midbrain dopamine neurones in rat brain slices by a selective D2 receptor antagonist L-741,626. Br.J.Pharmacol. 119 1491. Pillai et al (1998) Human D2 and D4 dopamine receptors couple through bg G-protein subunits to inwardly rectifying K+ channels (GIRK1) in a Xenopus oocyte expression system: selective antagonism by L-741,626 and L-745,870 respectively. Neuropharmacology 37 983. Millan et al (2000) S33084, a novel, potent, selective, and competitive antagonist at dopamine D3-receptors: II. Functional and behavioral profile compared with GR218,231 and L741,626. J.Pharmacol.Exp.Ther. 293 1063.
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Keywords: L-741,626, High, affinity, D2, antagonists, Dopamine, Receptors, dopaminergic
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