R&D Systems Inc. Tocris Bioscience Boston Biochem

GRK2i

Cat. No. 3594

GRK2i Trp-Lys-Lys-Glu-Leu-Arg-Asp-Ala-Tyr-Arg-Glu-Ala-Gln-Gln-Leu-Val-Gln-Arg-Val-Pro-Lys-Met-Lys-Asn-Lys-Pro-Arg-Ser

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Biological Activity

GRK2 inhibitory polypeptide that specifically inhibits Gβγ activation of GRK2. Corresponds to the Gβγ-binding domain and acts as a cellular Gβγ antagonist.

Technical Data

M.Wt:
3484.08
Formula:
C153H256N50O41S
Sequence:
WKKELRDAYREAQQLVQRVPKMKNKPRS
Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
CAS No:
148505-03-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Koch et al (1994) Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates Gβγ-mediated signaling. J.Biol.Chem. 269 6193. PMID: 8119963.

Macrez et al (1997) A βγ dimer derived from G13 transduces the angiotensin AT1 receptor signal to stimulation of Ca2+ channels in rat portal vein myocytes. J.Biol.Chem. 272 23180. PMID: 9287322.

Dang et al (2009) Two distinct mechanisms mediate acute μ-opioid receptor desensitization in native neurons. J.Neurosci. 29 3322. PMID: 19279269.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: GRK2i, supplier, GRK, inhibitory, polypeptide, Gbg, antagonists, Gβγ, Gbetagamma, G, protein, heterotrimeric

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