Cat. No. 3594
Biological ActivityGRK2 inhibitory polypeptide that specifically inhibits Gβγ activation of GRK2. Corresponds to the Gβγ-binding domain and acts as a cellular Gβγ antagonist.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Koch et al (1994) Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates Gβγ-mediated signaling. J.Biol.Chem. 269 6193. PMID: 8119963.
Macrez et al (1997) A βγ dimer derived from G13 transduces the angiotensin AT1 receptor signal to stimulation of Ca2+ channels in rat portal vein myocytes. J.Biol.Chem. 272 23180. PMID: 9287322.
Dang et al (2009) Two distinct mechanisms mediate acute μ-opioid receptor desensitization in native neurons. J.Neurosci. 29 3322. PMID: 19279269.
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Keywords: GRK2i, supplier, GRK, inhibitory, polypeptide, Gbg, antagonists, Gβγ, Gbetagamma, G, protein, heterotrimeric