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Org 12962 hydrochloride

Cat. No. 3585

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Chemical Name: 1-[6-Chloro-5-trifluoromethyl)-2-pyridinyl]-piperazine hydrochloride

Biological Activity

Selective 5-HT_2C receptor agonist (pEC₅₀ values are 7.01, 6.38 and 6.28 for 5-HT_2C, 5-HT_2A and 5-HT_2B respectively). Displays antiaversive effects in a rat model of panic-like anxiety.

Technical Data

M.Wt:

302.12

Formula:

C₁₀H₁₁CIF₃N₃.HCl

Solubility:

Soluble to 50 mM in water and to 100 mM in DMSO

Purity:

>99 %

Storage:

Desiccate at RT

CAS No:

210821-63-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Jenck et al (1998) Antiaversive effects of 5-HT_2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats. Eur.Neuropsychopharmacol. 8 161. PMID: 9716307.

Porter et al (1999) Functional characterization of agonists at recombinant human 5-HT_2A, 5-HT_2B and 5-HT_2C receptors in CHO-K1 cells. Br.J.Pharmacol. 128 13. PMID: 10498829.

Halford et al (2005) Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity. Curr.Drug Targets 6 201. PMID: 15777190.

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